98737-30-5Relevant articles and documents
Novel in vivo active anti-malarials based on a hydroxy-ethyl-amine scaffold
Ciana, Claire-Lise,Siegrist, Romain,Aissaoui, Hamed,Marx, Leo,Racine, Sophie,Meyer, Solange,Binkert, Christoph,De Kanter, Ruben,Fischli, Christoph,Wittlin, Sergio,Boss, Christoph
supporting information, p. 658 - 662 (2013/03/14)
A novel series of anti-malarials, based on a hydroxy-ethyl-amine scaffold, initially identified as peptidomimetic protease inhibitors is described. Combination of the hydroxy-ethyl-amine anti-malarial phramacophore with the known Mannich base pharmacophor
HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE
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Page 105, (2010/02/07)
The present invention relates to novel hydroxyethylamine compounds of formula (I): (I) having Asp2 (-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated-amyloid levels or-amyloid deposits, particularly Alzheimer's disease.