Benzoic acid (S)-1-[(S)-2-phenyl-2-(4-propylcarbamoyl-phenylamino)-ethyl]-pyrrolidin-3-yl ester

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Chemical Name:Benzoic acid (S)-1-[(S)-2-phenyl-2-(4-propylcarbamoyl-phenylamino)-ethyl]-pyrrolidin-3-yl ester
CAS No.:479687-38-2
Molecular Formula:C₂₉H₃₃N₃O₃
Molecular Weight:471.599
Hs Code.:

Synonyms:Benzoic acid (S)-1-[(S)-2-phenyl-2-(4-propylcarbamoyl-phenylamino)-ethyl]-pyrrolidin-3-yl ester

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Chemical Property of Benzoic acid (S)-1-[(S)-2-phenyl-2-(4-propylcarbamoyl-phenylamino)-ethyl]-pyrrolidin-3-yl ester

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Technology Process of Benzoic acid (S)-1-[(S)-2-phenyl-2-(4-propylcarbamoyl-phenylamino)-ethyl]-pyrrolidin-3-yl ester

There total 13 articles about Benzoic acid (S)-1-[(S)-2-phenyl-2-(4-propylcarbamoyl-phenylamino)-ethyl]-pyrrolidin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 7461-32-7
4-chloro-N-n-propylbenzamide

: 479687-34-8
Benzoic acid (S)-1-((S)-2-amino-2-phenyl-ethyl)-pyrrolidin-3-yl ester

: 479687-38-2
Benzoic acid (S)-1-[(S)-2-phenyl-2-(4-propylcarbamoyl-phenylamino)-ethyl]-pyrrolidin-3-yl ester

Guidance literature:: With caesium carbonate; johnphos; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In toluene; at 100 ℃;
DOI:10.1039/b204844b

Reference yield: 39.0%

: 223557-19-5
4-bromo-N-(propyl)benzamide

: 479687-34-8
Benzoic acid (S)-1-((S)-2-amino-2-phenyl-ethyl)-pyrrolidin-3-yl ester

: 479687-38-2
Benzoic acid (S)-1-[(S)-2-phenyl-2-(4-propylcarbamoyl-phenylamino)-ethyl]-pyrrolidin-3-yl ester

Guidance literature:: With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; In toluene; at 100 ℃;
DOI:10.1039/b204844b

Reference yield:

: 20989-17-7
(2S)-2-phenylglycinol

: 479687-38-2
Benzoic acid (S)-1-[(S)-2-phenyl-2-(4-propylcarbamoyl-phenylamino)-ethyl]-pyrrolidin-3-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / tetrahydrofuran

2: SOCl₂; Et₃N / CH₂Cl₂

3: 94 percent / aq. NaIO₄; RuCl₃ / acetonitrile / 1 h / 0 - 20 °C

4: 70 percent / Et₃N / ethyl acetate

5: 100 percent / aq. HCl / various solvent(s)

6: 42 percent / (o-biphen)P(t-Bu)2; Cs₂CO₃ / Pd₂(dba)3 / toluene / 100 °C

With hydrogenchloride; ruthenium trichloride; sodium periodate; thionyl chloride; caesium carbonate; triethylamine; johnphos; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; dichloromethane; ethyl acetate; toluene; acetonitrile;
DOI:10.1039/b204844b