7461-32-7

Usage

InChI:InChI=1/C10H12ClNO/c1-2-7-12-10(13)8-3-5-9(11)6-4-8/h3-6H,2,7H2,1H3,(H,12,13)

Upstream product

• 107-10-8 propylamine 
• 122-01-0 4-chloro-benzoyl chloride 
• 54979-12-3 N-(4-chlorobenzylidene)propan-1-amine 
• 104-88-1 4-chlorobenzaldehyde 
• 63591-89-9 1,3-dioxoisoindolin-2-yl 4-chlorobenzoate 
• 74-11-3 para-chlorobenzoic acid 
• 874-59-9 4-chlorobenzoyl bromide 

Downstream Products

• 39887-62-2 N-(n-Propyl)-4-chlorbenzimidylchlorid 
• 479687-38-2 Benzoic acid (S)-1-[(S)-2-phenyl-2-(4-propylcarbamoyl-phenylamino)-ethyl]-pyrrolidin-3-yl ester 
• 572923-17-2 4-(4-phenyl-2-oxo-oxazolidin-3-yl)-N-propyl-benzamide 
• 572923-16-1 4-(4-ethyl-2-oxo-oxazolidin-3-yl)-N-propyl-benzamide 
• 204970-97-8 (2'S,3S)-3-hydroxy-N-{2-[N-methyl-N-4-(N-propylaminocarbonyl)phenyl]amino-2-phenyl}ethylpyrrolidine 
• 473916-34-6 (2'S,3S)-3-benzoyloxy-N-{2-[N-methyl-N-4-(N-propylaminocarbonyl)phenyl]amino-2-phenyl}ethylpyrrolidine 
• 39549-63-8 N-propanoyl-4-chlorobenzamide 

Relevant academic research and scientific papers

Convenient metal-free direct oxidative amidation of aldehyde using dibromoisocyanuric acid under mild conditions

A facile method for the direct synthesis of amides from aldehydes is described. Amide bonds were synthesized by an oxidative amidation in the presence of dibromoisocyanuric acid (DBI). Treatment of aromatic and aliphatic aldehydes with dibromoisocyanuric acid generated acyl bromide intermediates, which were employed to react with a variety of secondary and primary amines to give amides. Through this reaction method, various amides were synthesized directly from aldehydes under mild conditions in high yields and short times. This facile and efficient procedure provides potential strategy for the direct synthesis of amides from aldehydes.

Visible-Light-Driven Oxidation of N -Alkylamides to Imides Using Oxone/H 2 O and Catalytic KBr

Imides are prepared conveniently by visible-light-driven oxidations of various N -alkylamides under mild conditions. The majority of the reactions proceed efficiently by using Oxone as the oxidant in the presence of a catalytic amount of KBr in H 2 O/CH 2 Cl 2 under irradiation by an 8 W white LED at room temperature. Experimental studies suggest that an imine, obtained from the substrate amide via a radical process, is the key intermediate.

Metal-free intermolecular C-O cross-coupling reactions: Synthesis of: N -hydroxyimide esters

Selectfluor-mediated intermolecular C-O cross coupling reaction for the synthesis of N-hydroxyimide esters was developed for the first time. The reaction is applicable to the coupling of readily available aryl and alkyl aldehydes with N-hydroxyphthalimide (NHPI) and N-hydroxysuccinimide (NHSI). The resulting active esters can be directly converted into amides in one pot.

A mild and clean method for oxidative formation of amides from aldehydes and amines

A metal-free direct oxidative formation of amides from aldehydes and amines using a hypervalent iodine(III) reagent or an ion-supported hypervalent iodine(III) reagent as a recyclable oxidant under mild conditions is reported. Georg Thieme Verlag Stuttgart.

11a-Methano-TXA compounds

The present invention provides novel 11a-methano-TXA compounds and intermediates and processs for their preparation. Further provided are methods for using these novel TXA analogs as inhibitors of thromboxane synthetase, rendering these analogs useful for a variety of pharmacological purposes. These pharmacological uses include anti-inflammatory, anti-thromobitc, and anti-asthma indications.

The Reaction between Cyanide Ion and Nitrones; a Novel Imidazole Synthesis

By contrast with the CN-diphenylnitrones, cold aqueous ethanolic potassium cyanide converts N-methyl-C-phenylnitrone into 1-methyl-4,5-diphenylimidazole.The scope of this reaction has been investigated, and shown to proceed via intermediate cyano-imines, some of which have been synthesised by alternative routes.