5-ethyl-6-(4-methoxy-phenyl)-2-thiopnen-2-yl-thieno[2,3-d]pyrimidin-4-ol

Base Information

Chemical Name:5-ethyl-6-(4-methoxy-phenyl)-2-thiopnen-2-yl-thieno[2,3-d]pyrimidin-4-ol
CAS No.:949528-66-9
Molecular Formula:C₁₉H₁₆N₂O₂S₂
Molecular Weight:368.48
Hs Code.:

Synonyms:5-ethyl-6-(4-methoxy-phenyl)-2-thiopnen-2-yl-thieno[2,3-d]pyrimidin-4-ol

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Chemical Property of 5-ethyl-6-(4-methoxy-phenyl)-2-thiopnen-2-yl-thieno[2,3-d]pyrimidin-4-ol

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Technology Process of 5-ethyl-6-(4-methoxy-phenyl)-2-thiopnen-2-yl-thieno[2,3-d]pyrimidin-4-ol

There total 6 articles about 5-ethyl-6-(4-methoxy-phenyl)-2-thiopnen-2-yl-thieno[2,3-d]pyrimidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.4%

: 1003-31-2
thiophene-2-carbonitrile

: 949528-65-8
2-amino-4-ethyl-5-(4-methoxy-phenyl)-thiophen-3-carboxylic acid ethyl ester

: 949528-66-9
5-ethyl-6-(4-methoxy-phenyl)-2-thiopnen-2-yl-thieno[2,3-d]pyrimidin-4-ol

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 110 ℃; for 36h;

Reference yield:

: 5703-26-4
4-Methoxyphenylacetaldehyde

: 949528-66-9
5-ethyl-6-(4-methoxy-phenyl)-2-thiopnen-2-yl-thieno[2,3-d]pyrimidin-4-ol

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 4 h / -10 - 20 °C

2: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

3: morpholine; sulfur / ethanol / 5 h / 80 °C

4: hydrogenchloride / 1,4-dioxane / 36 h / 110 °C

With morpholine; hydrogenchloride; Dess-Martin periodane; sulfur; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;

Reference yield:

: 104-01-8
4-Methoxyphenylacetic acid

: 949528-66-9
5-ethyl-6-(4-methoxy-phenyl)-2-thiopnen-2-yl-thieno[2,3-d]pyrimidin-4-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride / benzene / 3.5 h / 20 °C

2.1: N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; N,N-dimethyl-formamide; cadmium(II) chloride / acetonitrile / 0.67 h / -5 - 0 °C

2.2: pH 3

3.1: tetrahydrofuran / 4 h / -10 - 20 °C

4.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

5.1: morpholine; sulfur / ethanol / 5 h / 80 °C

6.1: hydrogenchloride / 1,4-dioxane / 36 h / 110 °C

With morpholine; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; oxalyl dichloride; Dess-Martin periodane; sulfur; N,N-dimethyl-formamide; cadmium(II) chloride; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; acetonitrile; benzene;