(S)-tert-butyl 4-(2-hydroxy-1-(2-nitrophenylamino) ethyl)piperidine-1-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 4-(2-hydroxy-1-(2-nitrophenylamino) ethyl)piperidine-1-carboxylate
CAS No.:1440754-72-2
Molecular Formula:C₁₈H₂₇N₃O₅
Molecular Weight:365.429
Hs Code.:

Synonyms:(S)-tert-butyl 4-(2-hydroxy-1-(2-nitrophenylamino) ethyl)piperidine-1-carboxylate

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Chemical Property of (S)-tert-butyl 4-(2-hydroxy-1-(2-nitrophenylamino) ethyl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of (S)-tert-butyl 4-(2-hydroxy-1-(2-nitrophenylamino) ethyl)piperidine-1-carboxylate

There total 3 articles about (S)-tert-butyl 4-(2-hydroxy-1-(2-nitrophenylamino) ethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: t-Butyl 4-[(1S)-1-amino-2-hydroxyethyl]-1-piperidinecarboxylate

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1440754-72-2
(S)-tert-butyl 4-(2-hydroxy-1-(2-nitrophenylamino) ethyl)piperidine-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 90 ℃; for 8h;

Reference yield:

: 1440754-66-4
tert-butyl 4-((S)-1-azido-2-oxo-2-((S)-2-oxo-4-phenyloxazolidin-3-yl)ethyl)piperidine-1-carboxylate

: 1440754-72-2
(S)-tert-butyl 4-(2-hydroxy-1-(2-nitrophenylamino) ethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate; methanol / 14 h / 20 °C

2: 5%-palladium/activated carbon; hydrogen / ethanol / 2 h / 20 °C / 760.05 Torr / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 8 h / 90 °C

With methanol; sodium tetrahydroborate; 5%-palladium/activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; ethanol;

Reference yield:

: 1613404-75-3
C₂₁H₂₈N₂O₅

: 1440754-72-2
(S)-tert-butyl 4-(2-hydroxy-1-(2-nitrophenylamino) ethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,4,6-Triisopropylbenzenesulfonyl azide; potassium hexamethylsilazane / toluene; tetrahydrofuran / -60 °C

1.2: 20 °C

2.1: sodium tetrahydroborate / methanol / 4 h / 20 °C

3.1: palladium on activated charcoal; hydrogen / ethanol / 2 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; 1-methyl-pyrrolidin-2-one / 6 h / 100 °C

With 1-methyl-pyrrolidin-2-one; sodium tetrahydroborate; palladium on activated charcoal; 2,4,6-Triisopropylbenzenesulfonyl azide; hydrogen; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; toluene;
DOI:10.1021/jm500632s