(S)-tert-butyl 4-(1-(2-nitrophenylamino)-2-(1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carbonyloxy)ethyl)piperidine-1-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 4-(1-(2-nitrophenylamino)-2-(1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carbonyloxy)ethyl)piperidine-1-carboxylate
CAS No.:1440754-88-0
Molecular Formula:C₃₆H₄₄N₆O₆S
Molecular Weight:688.848
Hs Code.:

(S)-tert-butyl 4-(1-(2-nitrophenylamino)-2-(1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carbonyloxy)ethyl)piperidine-1-carboxylate

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Chemical Property of (S)-tert-butyl 4-(1-(2-nitrophenylamino)-2-(1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carbonyloxy)ethyl)piperidine-1-carboxylate

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Technology Process of (S)-tert-butyl 4-(1-(2-nitrophenylamino)-2-(1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carbonyloxy)ethyl)piperidine-1-carboxylate

There total 9 articles about (S)-tert-butyl 4-(1-(2-nitrophenylamino)-2-(1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carbonyloxy)ethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1440754-34-6
1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxylic acid

: 1440754-72-2
(S)-tert-butyl 4-(2-hydroxy-1-(2-nitrophenylamino) ethyl)piperidine-1-carboxylate

: 1440754-88-0
(S)-tert-butyl 4-(1-(2-nitrophenylamino)-2-(1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carbonyloxy)ethyl)piperidine-1-carboxylate

Guidance literature:: With di-tert-butyl azodicarboxylate; In tetrahydrofuran; toluene;
DOI:10.1021/jm500632s

Reference yield:

: 1440754-78-8
C₁₂H₂₂N₄O₃

: 1440754-88-0
(S)-tert-butyl 4-(1-(2-nitrophenylamino)-2-(1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carbonyloxy)ethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium on activated charcoal; hydrogen / ethanol / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; 1-methyl-pyrrolidin-2-one / 6 h / 100 °C

3: di-tert-butyl azodicarboxylate / toluene; tetrahydrofuran

With 1-methyl-pyrrolidin-2-one; di-tert-butyl azodicarboxylate; palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; toluene;
DOI:10.1021/jm500632s

Reference yield:

: t-Butyl 4-[(1S)-1-amino-2-hydroxyethyl]-1-piperidinecarboxylate

: 1440754-88-0
(S)-tert-butyl 4-(1-(2-nitrophenylamino)-2-(1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carbonyloxy)ethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; 1-methyl-pyrrolidin-2-one / 6 h / 100 °C

2: di-tert-butyl azodicarboxylate / toluene; tetrahydrofuran

With 1-methyl-pyrrolidin-2-one; di-tert-butyl azodicarboxylate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; toluene;
DOI:10.1021/jm500632s