allyl 3-[dimethyl(thexyl)silyloxy]-2-[(R)-2-((R)-3-hydroxy-3-(methoxycarbonyl)-propionylamino)-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-5-methoxy-6-methylbenzoate

Base Information

Chemical Name:allyl 3-[dimethyl(thexyl)silyloxy]-2-[(R)-2-((R)-3-hydroxy-3-(methoxycarbonyl)-propionylamino)-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-5-methoxy-6-methylbenzoate
CAS No.:676347-29-8
Molecular Formula:C₃₁H₄₇N₃O₉SSi
Molecular Weight:665.88
Hs Code.:

allyl 3-[dimethyl(thexyl)silyloxy]-2-[(R)-2-((R)-3-hydroxy-3-(methoxycarbonyl)-propionylamino)-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-5-methoxy-6-methylbenzoate

Synonyms:allyl 3-[dimethyl(thexyl)silyloxy]-2-[(R)-2-((R)-3-hydroxy-3-(methoxycarbonyl)-propionylamino)-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-5-methoxy-6-methylbenzoate

Suppliers and Price of allyl 3-[dimethyl(thexyl)silyloxy]-2-[(R)-2-((R)-3-hydroxy-3-(methoxycarbonyl)-propionylamino)-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-5-methoxy-6-methylbenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of allyl 3-[dimethyl(thexyl)silyloxy]-2-[(R)-2-((R)-3-hydroxy-3-(methoxycarbonyl)-propionylamino)-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-5-methoxy-6-methylbenzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of allyl 3-[dimethyl(thexyl)silyloxy]-2-[(R)-2-((R)-3-hydroxy-3-(methoxycarbonyl)-propionylamino)-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-5-methoxy-6-methylbenzoate

There total 8 articles about allyl 3-[dimethyl(thexyl)silyloxy]-2-[(R)-2-((R)-3-hydroxy-3-(methoxycarbonyl)-propionylamino)-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-5-methoxy-6-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 83540-94-7
(R)-2-hydroxybutanedioic acid 1-methylester

: 173152-60-8
allyl 2-{(R)-2-amino-2-[3-methyl-1,2,4-oxadiazol-5-yl]-ethylsulfanylmethyl}-3-[dimethyl(thexyl)silyloxy]-5-methoxy-6-methylbenzoate

: 676347-29-8
allyl 3-[dimethyl(thexyl)silyloxy]-2-[(R)-2-((R)-3-hydroxy-3-(methoxycarbonyl)-propionylamino)-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-5-methoxy-6-methylbenzoate

Guidance literature:: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In acetonitrile; at 0 ℃; for 4h;
DOI:10.1021/jm0310232

Reference yield:

: 52344-94-2
methyl 3,5-dimethoxy-2-methylbenzoate

: 676347-29-8
allyl 3-[dimethyl(thexyl)silyloxy]-2-[(R)-2-((R)-3-hydroxy-3-(methoxycarbonyl)-propionylamino)-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-5-methoxy-6-methylbenzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 92 percent / POCl₃ / CH₂Cl₂ / 72 h / 40 °C

2.1: 86 percent / BCl₃ / CH₂Cl₂ / 4.5 h / 20 °C

3.1: 98 percent / aq. KOH / 0.5 h / 75 °C

4.1: N,N,N',N'-tetramethylguanidine / dimethylformamide / 0.5 h

4.2: 86 percent / dimethylformamide / 3 h

5.1: 90 percent / Et₃N / dimethylformamide / 6 h

6.1: 69 percent / TFA; Et₃SiH / CH₂Cl₂ / 18 h / 0 °C

7.1: 81 percent / EDC / acetonitrile / 4 h / 0 °C

With triethylsilane; potassium hydroxide; boron trichloride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; trichlorophosphate; N,N,N',N'-tetramethylguanidine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1.1: Vilsmeyer formylation;
DOI:10.1021/jm0310232

Reference yield:

: 67373-56-2
chlorodimethyl(1,1,2-trimethylpropyl)silane

: 676347-29-8
allyl 3-[dimethyl(thexyl)silyloxy]-2-[(R)-2-((R)-3-hydroxy-3-(methoxycarbonyl)-propionylamino)-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-5-methoxy-6-methylbenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / Et₃N / dimethylformamide / 6 h

2: 69 percent / TFA; Et₃SiH / CH₂Cl₂ / 18 h / 0 °C

3: 81 percent / EDC / acetonitrile / 4 h / 0 °C

With triethylsilane; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm0310232