dl-12-benzyloxy-1,2-dodecandiol

Base Information

• Chemical Name: dl-12-benzyloxy-1,2-dodecandiol
• CAS No.: 324010-82-4
• Molecular Formula: C₁₉H₃₂O₃
• Molecular Weight: 308.461
• Mol file: 324010-82-4.mol

Synonyms:dl-12-benzyloxy-1,2-dodecandiol

Chemical Property of dl-12-benzyloxy-1,2-dodecandiol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dl-12-benzyloxy-1,2-dodecandiol

There total 6 articles about dl-12-benzyloxy-1,2-dodecandiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1-benzyloxy-11-dodecene (324010-81-3) → dl-12-benzyloxy-1,2-dodecandiol (324010-82-4)

Guidance literature:

With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In water; acetone; tert-butyl alcohol; at 20 ℃; for 2h;

DOI:10.1016/S0040-4020(00)00904-2

Reference yield:

1,9-Nonanediol (3937-56-2) → dl-12-benzyloxy-1,2-dodecandiol (324010-82-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 51 percent / NaH / tetrahydrofuran / 2 h / Heating

2: pyridine / CH₂Cl₂ / 72 h / 20 °C

3: 4.2 g / NaI; NaHCO₃ / acetone / 72 h / 20 °C

4: 76 percent / Li₂CuCl₄ / tetrahydrofuran; diethyl ether / 2 h / 0 °C

5: 79 percent / 4-methylmorpholine N-oxide; OsO₄ / H₂O; 2-methyl-propan-2-ol; acetone / 2 h / 20 °C

With pyridine; osmium(VIII) oxide; dilithium tetrachlorocuprate; sodium hydride; sodium hydrogencarbonate; 4-methylmorpholine N-oxide; sodium iodide; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetone; tert-butyl alcohol;

DOI:10.1016/S0040-4020(00)00904-2

Reference yield:

benzyl bromide (100-39-0) → dl-12-benzyloxy-1,2-dodecandiol (324010-82-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 51 percent / NaH / tetrahydrofuran / 2 h / Heating

2: pyridine / CH₂Cl₂ / 72 h / 20 °C

3: 4.2 g / NaI; NaHCO₃ / acetone / 72 h / 20 °C

4: 76 percent / Li₂CuCl₄ / tetrahydrofuran; diethyl ether / 2 h / 0 °C

5: 79 percent / 4-methylmorpholine N-oxide; OsO₄ / H₂O; 2-methyl-propan-2-ol; acetone / 2 h / 20 °C

With pyridine; osmium(VIII) oxide; dilithium tetrachlorocuprate; sodium hydride; sodium hydrogencarbonate; 4-methylmorpholine N-oxide; sodium iodide; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetone; tert-butyl alcohol;

DOI:10.1016/S0040-4020(00)00904-2

upstream raw materials:

1-benzyloxy-11-dodecene

1,9-Nonanediol

benzyl bromide

9-(phenylmethoxy)nonan-1-ol