4-(2-methoxy-2-oxoethyl)-3-oxopiperazine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-(2-methoxy-2-oxoethyl)-3-oxopiperazine-1-carboxylic acid tert-butyl ester
• CAS No.: 930122-19-3
• Molecular Formula: C₁₂H₂₀N₂O₅
• Molecular Weight: 272.301
• Mol file: 930122-19-3.mol

Synonyms:4-(2-methoxy-2-oxoethyl)-3-oxopiperazine-1-carboxylic acid tert-butyl ester

Chemical Property of 4-(2-methoxy-2-oxoethyl)-3-oxopiperazine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-methoxy-2-oxoethyl)-3-oxopiperazine-1-carboxylic acid tert-butyl ester

There total 1 articles about 4-(2-methoxy-2-oxoethyl)-3-oxopiperazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-(t-butyloxycarbonyl)piperazin-2-one (76003-29-7) + bromoacetic acid methyl ester (96-32-2) → 4-(2-methoxy-2-oxoethyl)-3-oxopiperazine-1-carboxylic acid tert-butyl ester (930122-19-3)

Guidance literature:

4-(t-butyloxycarbonyl)piperazin-2-one; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.166667h; Inert atmosphere;

bromoacetic acid methyl ester; In N,N-dimethyl-formamide; mineral oil;

Reference yield: 91.0%

4-(2-methoxy-2-oxoethyl)-3-oxopiperazine-1-carboxylic acid tert-butyl ester (930122-19-3) → 2-(2-oxopiperazin-1-yl)acetic acid methyl ester (32705-79-6)

Guidance literature:

With trifluoroacetic acid;

Reference yield:

4-(2-methoxy-2-oxoethyl)-3-oxopiperazine-1-carboxylic acid tert-butyl ester (930122-19-3) → (1,3,4-trioxo-2-phenyl-octahydro-8-oxa-2,5,7a-triaza-cyclopenta[a]inden-5-yl)-acetic acid methyl ester

Guidance literature:

Multi-step reaction with 3 steps

1: CF₃COOH / methoxybenzene / 1.5 h

2: 1.76 g / Et₃N; Na₂WO₄; aq. H₂O₂ / methanol / 3 h / 0 - 20 °C / pH 7.5

3: 66 percent / tetrahydrofuran / 2 h / 65 °C

With sodium tungstate; dihydrogen peroxide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; methoxybenzene;

DOI:10.1515/znb-2006-0410

upstream raw materials:

4-(t-butyloxycarbonyl)piperazin-2-one

bromoacetic acid methyl ester

Downstream raw materials:

2-(2-oxopiperazin-1-yl)acetic acid methyl ester