5-(2,4-bis(benzyloxy)-5-ethylphenyl)isoxazole-3-carboxylic acid ethylamide

Base Information

Chemical Name:5-(2,4-bis(benzyloxy)-5-ethylphenyl)isoxazole-3-carboxylic acid ethylamide
CAS No.:1001385-72-3
Molecular Formula:C₂₈H₂₈N₂O₄
Molecular Weight:456.541
Hs Code.:

Synonyms:5-(2,4-bis(benzyloxy)-5-ethylphenyl)isoxazole-3-carboxylic acid ethylamide

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Chemical Property of 5-(2,4-bis(benzyloxy)-5-ethylphenyl)isoxazole-3-carboxylic acid ethylamide

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Technology Process of 5-(2,4-bis(benzyloxy)-5-ethylphenyl)isoxazole-3-carboxylic acid ethylamide

There total 7 articles about 5-(2,4-bis(benzyloxy)-5-ethylphenyl)isoxazole-3-carboxylic acid ethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.06%

: 5-(2,4-dibenzyloxy-5-vinylphenyl)-N-ethylisoxazole-3-carboxamide

: 1001385-72-3
5-(2,4-bis(benzyloxy)-5-ethylphenyl)isoxazole-3-carboxylic acid ethylamide

Guidance literature:: With tris(triphenylphosphine)rhodium(l) chloride; hydrogen; In methanol; at 25 - 50 ℃; for 12h; under 2585.81 Torr;

Reference yield: 85.0%

: 1001385-71-2
5-(2,4-bis(benzyloxy)-5-ethylphenyl)isoxazole-3-carboxylic acid ethyl ester

: 75-04-7,85404-22-4
ethylamine

: 1001385-72-3
5-(2,4-bis(benzyloxy)-5-ethylphenyl)isoxazole-3-carboxylic acid ethylamide

Guidance literature:: In methanol; ethanol; for 3h; Heating;
DOI:10.1021/jm701018h

Reference yield:

: 747413-70-3
5-(2,4-bis(benzyloxy)-5-bromophenyl)isoxazole-3-carboxylic acid ethyl ester

: 1001385-72-3
5-(2,4-bis(benzyloxy)-5-ethylphenyl)isoxazole-3-carboxylic acid ethylamide

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol

2: caesium carbonate / water; tetrahydrofuran / 12 h / 25 - 80 °C / Inert atmosphere

3: hydrogen; tris(triphenylphosphine)rhodium(l) chloride / methanol / 12 h / 25 - 50 °C / 2585.81 Torr

With tris(triphenylphosphine)rhodium(l) chloride; hydrogen; caesium carbonate; In tetrahydrofuran; methanol; ethanol; water;