2-fluoro-5-((2R,4R)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid hydrochloride

Base Information

Chemical Name:2-fluoro-5-((2R,4R)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid hydrochloride
CAS No.:1451372-95-4
Molecular Formula:C₂₉H₂₆FNO₃*ClH
Molecular Weight:491.99
Hs Code.:

Synonyms:2-fluoro-5-((2R,4R)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid hydrochloride

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Chemical Property of 2-fluoro-5-((2R,4R)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid hydrochloride

Chemical Property:

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Technology Process of 2-fluoro-5-((2R,4R)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid hydrochloride

There total 12 articles about 2-fluoro-5-((2R,4R)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 2-fluoro-5-((2R,4R)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid

: 1451372-95-4
2-fluoro-5-((2R,4R)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; for 0.166667h;

Reference yield:

: 1451372-04-5
methyl 2-fluoro-5-((2R,4R)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoate

: 1451372-95-4
2-fluoro-5-((2R,4R)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid hydrochloride

Guidance literature:: methyl 2-fluoro-5-((2R,4R)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoate; With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 80 ℃; for 2h;

With hydrogenchloride; In diethyl ether; for 0.166667h;

Reference yield:

: 51939-71-0
chroman-2-carboxylic acid

: 1451372-95-4
2-fluoro-5-((2R,4R)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 11 steps

1.1: 1-phenylpropylamine / acetonitrile; tert-butyl methyl ether / 6 h / 20 °C

1.2: 0 °C

2.1: thionyl chloride / 1,2-dichloro-ethane / 1 h / 0 - 20 °C / Reflux

2.3: 1 h / 0 °C

3.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 0 - 70 °C

4.1: acetonitrile / 50 °C

5.1: magnesium sulfate; potassium permanganate / water; acetone / 16 h / 0 - 20 °C

6.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

6.2: -78 - 20 °C / Inert atmosphere

7.1: sodium carbonate / water; toluene; ethanol / 0.33 h / Inert atmosphere

7.2: 1 h / 65 °C / Inert atmosphere

8.1: palladium 10% on activated carbon; hydrogen / methanol

9.1: hydrogenchloride / methanol; dichloromethane / 20 °C

9.2: CHIRAL IA; DEA

10.1: lithium hydroxide monohydrate; water / methanol; tetrahydrofuran / 2 h / 80 °C

11.1: hydrogenchloride / diethyl ether / 0.17 h

With hydrogenchloride; potassium permanganate; thionyl chloride; lithium hydroxide monohydrate; dimethylsulfide borane complex; palladium 10% on activated carbon; 1-phenylpropylamine; water; hydrogen; potassium hexamethylsilazane; sodium carbonate; magnesium sulfate; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; tert-butyl methyl ether; water; 1,2-dichloro-ethane; acetone; toluene; acetonitrile;