diethyl (+/-)-N-(2-bromo-3-methylbutanoyl)-N-(2,4-dimethoxybenzyl)aminomalonate

Base Information

Chemical Name:diethyl (+/-)-N-(2-bromo-3-methylbutanoyl)-N-(2,4-dimethoxybenzyl)aminomalonate
CAS No.:94271-65-5
Molecular Formula:C₂₁H₃₀BrNO₇
Molecular Weight:488.376
Hs Code.:

Synonyms:diethyl (+/-)-N-(2-bromo-3-methylbutanoyl)-N-(2,4-dimethoxybenzyl)aminomalonate

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Chemical Property of diethyl (+/-)-N-(2-bromo-3-methylbutanoyl)-N-(2,4-dimethoxybenzyl)aminomalonate

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Technology Process of diethyl (+/-)-N-(2-bromo-3-methylbutanoyl)-N-(2,4-dimethoxybenzyl)aminomalonate

There total 1 articles about diethyl (+/-)-N-(2-bromo-3-methylbutanoyl)-N-(2,4-dimethoxybenzyl)aminomalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 27109-47-3,27318-02-1,66067-58-1,52574-82-0
2-bromoisovaleryl chloride

: 81902-49-0
diethyl N-(2,4-dimethoxybenzyl)-amino-malonate

: 94271-65-5
diethyl (+/-)-N-(2-bromo-3-methylbutanoyl)-N-(2,4-dimethoxybenzyl)aminomalonate

Guidance literature:: With triethylamine; In benzene; for 0.5h; Ambient temperature;

Reference yield: 97.0%

: 94271-65-5
diethyl (+/-)-N-(2-bromo-3-methylbutanoyl)-N-(2,4-dimethoxybenzyl)aminomalonate

: 94271-66-6
diethyl (+/-)-3-isopropyl-1-(2,4-dimethoxybenzyl)-4-oxo-2,2-azetidinedicarboxylate

Guidance literature:: With triethylamine; In benzene; for 30h; Heating;

Reference yield:

: 94271-65-5
diethyl (+/-)-N-(2-bromo-3-methylbutanoyl)-N-(2,4-dimethoxybenzyl)aminomalonate

: 4-((2S,3S)-3-Isopropyl-4-oxo-azetidin-2-yl)-3-oxo-butyric acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 97 percent / triethylamine / benzene / 30 h / Heating

2: H₂O, NaCl / dimethylsulfoxide / 180 °C

3: aq. NaOH / ethanol / 0.25 h / 0 °C

4: 1.) ethyl chloroformate, triethylamine / 1.) THF, -15 deg C, 2.) ether, RT

5: 74 percent / tetrahydrofuran; H₂O / Irradiation

6: CH₂Cl₂ / Ambient temperature

7: K₂S₂O₈, Na₂HPO₄*2H₂O / acetonitrile; H₂O / 4 h / Heating

8: 88 percent / H₂ / Pd-C / ethanol

9: 1,1'-carbonyldiimidazole / 1.) CH₃CN, 30 min, RT, 2.) 12 h

With sodium hydroxide; disodium hydrogenphosphate; dipotassium peroxodisulfate; water; hydrogen; chloroformic acid ethyl ester; triethylamine; 1,1'-carbonyldiimidazole; sodium chloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile; benzene;