pGlu-His(Trt)-azPro-tritylamide

Base Information

Chemical Name:pGlu-His(Trt)-azPro-tritylamide
CAS No.:500771-01-7
Molecular Formula:C₅₃H₄₉N₇O₄
Molecular Weight:848.017
Hs Code.:

Synonyms:pGlu-His(Trt)-azPro-tritylamide

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Chemical Property of pGlu-His(Trt)-azPro-tritylamide

Chemical Property:

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Technology Process of pGlu-His(Trt)-azPro-tritylamide

There total 4 articles about pGlu-His(Trt)-azPro-tritylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 164166-90-9
L-pyroglutamyl-L-histidine (N^im-trityl) methyl ester

: 500771-01-7
pGlu-His(Trt)-azPro-tritylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / 1 N aq. NaOH / dimethylformamide / 1.67 h / 0 °C

2: tetramethylfluoroformamidinium hexafluorophosphate; HOAt; collidine / TFA / dimethylformamide / pH 6

With 2,3,5-trimethyl-pyridine; sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/ja020994o

Reference yield:

: 98-79-3
L-Pyroglutamic acid

: 500771-01-7
pGlu-His(Trt)-azPro-tritylamide

Guidance literature:: Multi-step reaction with 3 steps

1: HATu; HOAT; DIEA / dimethylformamide / pH 6.8

2: 53 percent / 1 N aq. NaOH / dimethylformamide / 1.67 h / 0 °C

3: tetramethylfluoroformamidinium hexafluorophosphate; HOAt; collidine / TFA / dimethylformamide / pH 6

With 2,3,5-trimethyl-pyridine; sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/ja020994o

Reference yield:

: 32946-56-8
N(τ)-(triphenylmethyl)-L-histidine methyl ester hydrochloride

: 500771-01-7
pGlu-His(Trt)-azPro-tritylamide

Guidance literature:: Multi-step reaction with 3 steps

1: HATu; HOAT; DIEA / dimethylformamide / pH 6.8

2: 53 percent / 1 N aq. NaOH / dimethylformamide / 1.67 h / 0 °C

3: tetramethylfluoroformamidinium hexafluorophosphate; HOAt; collidine / TFA / dimethylformamide / pH 6

With 2,3,5-trimethyl-pyridine; sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/ja020994o