(R,R)-(+)-1,4-DIMETHOXY-2,3-BUTANEDIOL

Base Information

• Chemical Name: (R,R)-(+)-1,4-DIMETHOXY-2,3-BUTANEDIOL
• CAS No.: 33507-82-3
• Molecular Formula: C6H14O4
• Molecular Weight: 150.17
• Hs Code.: 2909499000
• Mol file: 33507-82-3.mol

Synonyms:2,3-Butanediol,1,4-dimethoxy-, (R,R)- (8CI);2,3-Butanediol, 1,4-dimethoxy-, [R-(R*,R*)]-;1,4-Di-O-methyl-D-threitol;(2R,3R)-1,4-Dimethoxybutane-2,3-diol;(R,R)-(+)-1,4-Dimethoxy-2,3-butanediol;

Chemical Property of (R,R)-(+)-1,4-DIMETHOXY-2,3-BUTANEDIOL

Chemical Property:

• Vapor Pressure: 0.00142mmHg at 25°C
• Melting Point: 28-30 °C
• Refractive Index: 1.446
• Boiling Point: 263.8 °C at 760 mmHg
• PKA: 13.27±0.20(Predicted)
• Flash Point: 113.3 °C
• PSA: 58.92000
• Density: 1.103 g/cm³
• LogP: -0.99900
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(R,R)-(+)-1,4-Dimethoxy-2,3-butanediol ≥99.0% (sum of enantiomers, GC) ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of (R,R)-(+)-1,4-DIMETHOXY-2,3-BUTANEDIOL

There total 1 articles about (R,R)-(+)-1,4-DIMETHOXY-2,3-BUTANEDIOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (+)-(2R,3R)-1,4-dimethoxy-2,3-butanediol (33507-82-3)

Guidance literature:

2,3-O-Isopropyliden-1,4-di-O-methyl-D-threitol, H2SO4;

Reference yield: 79.0%

(+)-(2R,3R)-1,4-dimethoxy-2,3-butanediol (33507-82-3) + 3-(benzyloxy)-2,2-dimethyl-5-hexenal (123363-93-9) → (4R,5R)-2-(2-Benzyloxy-1,1-dimethyl-pent-4-enyl)-4,5-bis-methoxymethyl-[1,3]dioxolane (115378-45-5,130697-06-2)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 0.166667h; Heating;

DOI:10.1016/S0040-4020(01)81517-9

Reference yield:

(+)-(2R,3R)-1,4-dimethoxy-2,3-butanediol (33507-82-3) → (Z)-4-Hydroxy-1-[(1R,2R)-2-((Z)-4-hydroxy-2-oxo-4-phenyl-but-3-enyloxy)-3-methoxy-1-methoxymethyl-propoxy]-4-phenyl-but-3-en-2-one

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride

2.1: sodium amide / tetrahydrofuran / 20 °C

2.2: tetrahydrofuran / Heating

With sodium hydride; sodium amide; In tetrahydrofuran;

DOI:10.1002/anie.200502477

Downstream raw materials:

(4R,5R)-2-(2-Benzyloxy-1,1-dimethyl-pent-4-enyl)-4,5-bis-methoxymethyl-[1,3]dioxolane

[(1R,2R)-2-(Cyclohex-1-enyloxy)-3-methoxy-1-methoxymethyl-propoxy]-trimethyl-silane

(R)-3-Benzyloxy-4-((4R,5R)-4,5-bis-methoxymethyl-[1,3]dioxolan-2-yl)-4-methyl-pentan-1-ol

(R)-3-Benzyloxy-4-((4R,5R)-4,5-bis-methoxymethyl-[1,3]dioxolan-2-yl)-4-methyl-pentanal