123363-93-9

Upstream product

• 123363-92-8 2-<2-(benzyloxy)-1,1-dimethyl-4-pentenyl>-1,3-dioxolane 
• 67213-30-3 2-(1,3-dioxolan-2-yl)-2-methylpropanal 
• 32935-42-5 2-(1,1-dimethyl-2-hydroxyethyl)-1,3-dioxolane 
• 100-44-7 benzyl chloride 
• 67213-31-4 2-(2-hydroxy-1,1-dimethyl-4-pentenyl)-1,3-dioxolane 

Downstream Products

• 115378-45-5 (4R,5R)-2-(2-Benzyloxy-1,1-dimethyl-pent-4-enyl)-4,5-bis-methoxymethyl-[1,3]dioxolane 
• 123363-94-0 3-(benzyloxy)-2,2-dimethyl-5-hexen-1-ol 
• 123363-95-1 <4-(benzyloxy)tetrahydro-5,5-dimethyl-2H-pyran-2-yl>-methanol 
• 75099-06-8 (2R*,4S*)-4-(benzyloxy)tetrahydro-5,5-dimethyl-2H-pyran-2-carboxamide 
• 123363-96-2 4-(benzyloxy)tetrahydro-5,5-dimethyl-2H-pyran-2-carboxylic acid 
• 75099-07-9 (2S,4R)-4-Benzyloxy-5,5-dimethyl-tetrahydro-pyran-2-carboximidic acid methyl ester 
• 85199-44-6 N-<<(2R*,4S*)-4-(benzyloxy)tetrahydro-5,5-dimethyl-2H-pyran-2-yl>methoxymethyl>-α-acetoxyphenylacetamide 
• 115378-49-9 (R)-3,5-bis(benzyloxy)-2,2-dimethylpentanal 
• 115378-51-3 (R)-6,8-bis(benzyloxy)-5,5-dimethyl-1-octen-4-one 
• 115378-47-7 (R)-3-Benzyloxy-4-((4R,5R)-4,5-bis-methoxymethyl-[1,3]dioxolan-2-yl)-4-methyl-pentan-1-ol 
• 115378-46-6 (R)-3-Benzyloxy-4-((4R,5R)-4,5-bis-methoxymethyl-[1,3]dioxolan-2-yl)-4-methyl-pentanal 
• 115378-48-8 (4R,5R)-2-((R)-2,4-Bis-benzyloxy-1,1-dimethyl-butyl)-4,5-bis-methoxymethyl-[1,3]dioxolane 
• 130697-06-2 (4R,5R)-2-((S)-2-Benzyloxy-1,1-dimethyl-pent-4-enyl)-4,5-bis-methoxymethyl-[1,3]dioxolane 
• 115378-45-5 (4R,5R)-2-((R)-2-Benzyloxy-1,1-dimethyl-pent-4-enyl)-4,5-bis-methoxymethyl-[1,3]dioxolane 

Relevant academic research and scientific papers

A FORMAL SYNTHESIS OF APLASMOMYCIN. ASSEMBLY OF THE C3-C17 SEGMENT BASED ON 1,3- AND 1,5- ASYMMETRIC REDUCTIONS

The C3 - C17 segment of a boron containing ionophoric antibiotic aplasmomycin (1), the key intermediate in Corey's total synthesis of 1, was stereoselectively synthesized in an optically active form.This synthesis involved stereoselective construction of the two segments, (+)-dithiane 3 (C3-C11) and (+)-aldehyde 4 (C12-C17), based on remote controlled asymmetric reductions of the corresponding ketones as key steps and connection of 3 and 4 through the trans-double bond to elaborate the (+)-dithiane 2 (C3-C17), the key intermediate in Corey's total synthesis of 1.

STEREOCONTROLLED TOTAL SYNTHESIS OF (+)-PEDERINE

A mild one-pot method for the synthesis of acyclic N-(1-methoxyalkyl)amides starting from carboxylic acid and methyl imidates has been developed and applied to the first total synthesis of (+)-pederine (1), a potent insect poison.Furthermore, the stereocontrolled total synthesis of 1 was also achieved by employing acid catalyzed double alkoxy-exchange reaction of N-(1-methoxyalkyl)amide group as key step.