(3R)-tert-butyl 3-(1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)piperidine-1-carboxylate

Base Information

Chemical Name:(3R)-tert-butyl 3-(1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)piperidine-1-carboxylate
CAS No.:1071018-45-5
Molecular Formula:C₂₈H₃₉NO₅
Molecular Weight:469.621
Hs Code.:

Synonyms:(3R)-tert-butyl 3-(1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)piperidine-1-carboxylate

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Chemical Property of (3R)-tert-butyl 3-(1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)piperidine-1-carboxylate

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Technology Process of (3R)-tert-butyl 3-(1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)piperidine-1-carboxylate

There total 4 articles about (3R)-tert-butyl 3-(1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 884512-19-0
(3R)-1-(tert-butoxycarbonyl)-3-(2-phenoxybenzoyl)piperidine

: 634590-61-7
(4-methoxybutyl)magnesium chloride

: 1071018-45-5
(3R)-tert-butyl 3-(1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)piperidine-1-carboxylate

Guidance literature:: (3R)-1-(tert-butoxycarbonyl)-3-(2-phenoxybenzoyl)piperidine; (4-methoxybutyl)magnesium chloride; In tetrahydrofuran; at -10 - 20 ℃;

With ammonium chloride; In tetrahydrofuran;

Reference yield:

: 163438-09-3
(R)-1-Boc-nipecotic acid

: 1071018-45-5
(3R)-tert-butyl 3-(1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2: tetrahydrofuran / 0.5 h / -10 - 20 °C

3: tetrahydrofuran / -10 - 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;

Reference yield:

: 884510-86-5
(R)-tert-butyl 3-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate

: 1071018-45-5
(3R)-tert-butyl 3-(1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 0.5 h / -10 - 20 °C

2: tetrahydrofuran / -10 - 20 °C

In tetrahydrofuran;