(E)-1-(4-(4-chloro-3-methylbenzoyl)piperazin-1-yl)-3-(4-methoxyphenyl)prop-2-en-1-one

Base Information

Chemical Name:(E)-1-(4-(4-chloro-3-methylbenzoyl)piperazin-1-yl)-3-(4-methoxyphenyl)prop-2-en-1-one
CAS No.:1599432-04-8
Molecular Formula:C₂₂H₂₃ClN₂O₃
Molecular Weight:398.889
Hs Code.:

Synonyms:(E)-1-(4-(4-chloro-3-methylbenzoyl)piperazin-1-yl)-3-(4-methoxyphenyl)prop-2-en-1-one

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Chemical Property of (E)-1-(4-(4-chloro-3-methylbenzoyl)piperazin-1-yl)-3-(4-methoxyphenyl)prop-2-en-1-one

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Technology Process of (E)-1-(4-(4-chloro-3-methylbenzoyl)piperazin-1-yl)-3-(4-methoxyphenyl)prop-2-en-1-one

There total 3 articles about (E)-1-(4-(4-chloro-3-methylbenzoyl)piperazin-1-yl)-3-(4-methoxyphenyl)prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 7697-29-2
4-chloro-3-methylbenzoic acid

: (E)-3-(4-methoxyphenyl)-1-(piperazin-1-yl)prop-2-en-1-one hydrochloride

: 1599432-04-8
(E)-1-(4-(4-chloro-3-methylbenzoyl)piperazin-1-yl)-3-(4-methoxyphenyl)prop-2-en-1-one

Guidance literature:: With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1021/jm4019355

Reference yield:

: 1599431-92-1
(E)-tert-butyl 4-(3-(4-methoxyphenyl)acryloyl)piperazine-1-carboxylate

: 1599432-04-8
(E)-1-(4-(4-chloro-3-methylbenzoyl)piperazin-1-yl)-3-(4-methoxyphenyl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

2: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C

With hydrogenchloride; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm4019355

Reference yield:

: 943-89-5
(E)-3-(4-methoxyphenyl)acrylic acid

: 1599432-04-8
(E)-1-(4-(4-chloro-3-methylbenzoyl)piperazin-1-yl)-3-(4-methoxyphenyl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

3: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C

With hydrogenchloride; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm4019355