(1S,2S,(S)S)-1-phenyl-2-[2-(p-tolylsulfinyl)phenyl]-1-trimethylsilyloxypropane

Base Information

• Chemical Name: (1S,2S,(S)S)-1-phenyl-2-[2-(p-tolylsulfinyl)phenyl]-1-trimethylsilyloxypropane
• CAS No.: 738617-37-3
• Molecular Formula: C₂₅H₃₀O₂SSi
• Molecular Weight: 422.663
• Mol file: 738617-37-3.mol

Synonyms:(1S,2S,(S)S)-1-phenyl-2-[2-(p-tolylsulfinyl)phenyl]-1-trimethylsilyloxypropane

Chemical Property of (1S,2S,(S)S)-1-phenyl-2-[2-(p-tolylsulfinyl)phenyl]-1-trimethylsilyloxypropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S,(S)S)-1-phenyl-2-[2-(p-tolylsulfinyl)phenyl]-1-trimethylsilyloxypropane

There total 3 articles about (1S,2S,(S)S)-1-phenyl-2-[2-(p-tolylsulfinyl)phenyl]-1-trimethylsilyloxypropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

trimethylsilyl trifluoromethanesulfonate (27607-77-8) + (1S,2S)-1-Phenyl-2-[2-((S)-toluene-4-sulfinyl)-phenyl]-propan-1-ol (302934-18-5) → (1S,2S,(S)S)-1-phenyl-2-[2-(p-tolylsulfinyl)phenyl]-1-trimethylsilyloxypropane (738617-37-3)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 0.333333h;

DOI:10.1016/j.tet.2004.04.051

Reference yield:

benzaldehyde (100-52-7) → (1S,2S,(S)S)-1-phenyl-2-[2-(p-tolylsulfinyl)phenyl]-1-trimethylsilyloxypropane (738617-37-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi; i-Pr₂NH / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: 65 percent / hexane; tetrahydrofuran / 0.25 h / -78 °C

2.1: 94 percent / 2,6-lutidine / CH₂Cl₂ / 0.33 h / 0 °C

With 2,6-dimethylpyridine; n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1016/j.tet.2004.04.051

Reference yield:

(S)-1-ethyl-2-(p-tolylsulfinyl)benzene (302934-10-7) → (1S,2S,(S)S)-1-phenyl-2-[2-(p-tolylsulfinyl)phenyl]-1-trimethylsilyloxypropane (738617-37-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi; i-Pr₂NH / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: 65 percent / hexane; tetrahydrofuran / 0.25 h / -78 °C

2.1: 94 percent / 2,6-lutidine / CH₂Cl₂ / 0.33 h / 0 °C

With 2,6-dimethylpyridine; n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1016/j.tet.2004.04.051

upstream raw materials:

trimethylsilyl trifluoromethanesulfonate

(1S,2S)-1-Phenyl-2-[2-((S)-toluene-4-sulfinyl)-phenyl]-propan-1-ol

benzaldehyde

(S)-1-ethyl-2-(p-tolylsulfinyl)benzene