1-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-1-(3,5-difluorophenyl)-2,2-dimethylpropan-1-ol

Base Information

Chemical Name:1-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-1-(3,5-difluorophenyl)-2,2-dimethylpropan-1-ol
CAS No.:820971-10-6
Molecular Formula:C₂₇H₂₇Cl₂F₂NO
Molecular Weight:490.42
Hs Code.:

Synonyms:1-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-1-(3,5-difluorophenyl)-2,2-dimethylpropan-1-ol

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Chemical Property of 1-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-1-(3,5-difluorophenyl)-2,2-dimethylpropan-1-ol

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Technology Process of 1-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-1-(3,5-difluorophenyl)-2,2-dimethylpropan-1-ol

There total 1 articles about 1-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-1-(3,5-difluorophenyl)-2,2-dimethylpropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 359401-92-6
{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-(3,5-difluorophenyl)methanone

: 677-22-5
tert-butylmagnesium chloride

: 820971-10-6
1-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-1-(3,5-difluorophenyl)-2,2-dimethylpropan-1-ol

Guidance literature:: {1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-(3,5-difluorophenyl)methanone; tert-butylmagnesium chloride; In tetrahydrofuran; at -78 ℃; for 1h;

With sodium hydroxide; sodium hydrogencarbonate; pH=8 - 9;

Reference yield:

: 820971-10-6
1-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-1-(3,5-difluorophenyl)-2,2-dimethylpropan-1-ol

: 820971-11-7
1-[bis(4-chlorophenyl)methyl]-3-[1-(3,5-difluorophenyl)-2,2-dimethylpropylidene]azetidine

Guidance literature:: 1-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-1-(3,5-difluorophenyl)-2,2-dimethylpropan-1-ol; With diethylamino-sulfur trifluoride; In dichloromethane; at -78 - 45 ℃; for 4h;

With sodium hydroxide; sodium hydrogencarbonate; In dichloromethane; pH=8 - 9;

Reference yield:

: 820971-10-6
1-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-1-(3,5-difluorophenyl)-2,2-dimethylpropan-1-ol

: 820971-13-9
C₂₆H₂₄Cl₂F₃N

Guidance literature:: 1-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-1-(3,5-difluorophenyl)-2,2-dimethylpropan-1-ol; With pyridine hydrogenfluoride; In dichloromethane; at 42 ℃; for 9h;

With sodium hydroxide; sodium hydrogencarbonate; In dichloromethane; pH=8 - 9;