N-(4-fluorophenyl)-1-(methylsulfonyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine

Base Information

Chemical Name:N-(4-fluorophenyl)-1-(methylsulfonyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine
CAS No.:1400286-48-7
Molecular Formula:C₁₇H₁₄FN₅O₂S
Molecular Weight:371.395
Hs Code.:

Synonyms:N-(4-fluorophenyl)-1-(methylsulfonyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine

Suppliers and Price of N-(4-fluorophenyl)-1-(methylsulfonyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-fluorophenyl)-1-(methylsulfonyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(4-fluorophenyl)-1-(methylsulfonyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine

There total 8 articles about N-(4-fluorophenyl)-1-(methylsulfonyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1400287-02-6
tert-butyl 4-(6-(4-fluorophenylamino)-1-(methylsulfonyl)-1H-pyrrolo[3,2-c]pyridin-2-yl)-1H-pyrazole-1-carboxylate

: 1400286-48-7
N-(4-fluorophenyl)-1-(methylsulfonyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine

Guidance literature:: With water; sodium hydroxide; In ethanol; at 40 ℃; for 4h;

Reference yield:

: 800402-12-4
2-chloro-4-amino-5-iodopyridine

: 1400286-48-7
N-(4-fluorophenyl)-1-(methylsulfonyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 17.67 h / 20 °C / Cooling with ice

2: sodium hydroxide / tetrahydrofuran

3: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 60 °C / Microwave irradiation

4: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / water; tert-butyl alcohol / 1.5 h / 80 °C / Microwave irradiation

5: sodium hydroxide; water / ethanol / 4 h / 40 °C

With water; caesium carbonate; triethylamine; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; tert-butyl XPhos; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1093193-29-3
4-ethynyl-1H-pyrazole-1-carboxylate tert-butyl ester

: 1400286-48-7
N-(4-fluorophenyl)-1-(methylsulfonyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 60 °C / Microwave irradiation

2: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / water; tert-butyl alcohol / 1.5 h / 80 °C / Microwave irradiation

3: sodium hydroxide; water / ethanol / 4 h / 40 °C

With water; caesium carbonate; triethylamine; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; tert-butyl XPhos; In ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;