tert-butyl 4-(6-(4-fluorophenylamino)-1-(methylsulfonyl)-1H-pyrrolo[3,2-c]pyridin-2-yl)-1H-pyrazole-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(6-(4-fluorophenylamino)-1-(methylsulfonyl)-1H-pyrrolo[3,2-c]pyridin-2-yl)-1H-pyrazole-1-carboxylate
CAS No.:1400287-02-6
Molecular Formula:C₂₂H₂₂FN₅O₄S
Molecular Weight:471.512
Hs Code.:

Synonyms:tert-butyl 4-(6-(4-fluorophenylamino)-1-(methylsulfonyl)-1H-pyrrolo[3,2-c]pyridin-2-yl)-1H-pyrazole-1-carboxylate

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Chemical Property of tert-butyl 4-(6-(4-fluorophenylamino)-1-(methylsulfonyl)-1H-pyrrolo[3,2-c]pyridin-2-yl)-1H-pyrazole-1-carboxylate

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Technology Process of tert-butyl 4-(6-(4-fluorophenylamino)-1-(methylsulfonyl)-1H-pyrrolo[3,2-c]pyridin-2-yl)-1H-pyrazole-1-carboxylate

There total 9 articles about tert-butyl 4-(6-(4-fluorophenylamino)-1-(methylsulfonyl)-1H-pyrrolo[3,2-c]pyridin-2-yl)-1H-pyrazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400286-65-8
tert-butyl 4-(6-chloro-1-(methylsulfonyl)-1H-pyrrolo[3,2-c]pyridin-2-yl)-1H-pyrazole-1-carboxylate

: 371-40-4
4-fluoroaniline

: 1400287-02-6
tert-butyl 4-(6-(4-fluorophenylamino)-1-(methylsulfonyl)-1H-pyrrolo[3,2-c]pyridin-2-yl)-1H-pyrazole-1-carboxylate

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In water; tert-butyl alcohol; at 80 ℃; for 1.5h; Microwave irradiation;

Reference yield:

: 800402-12-4
2-chloro-4-amino-5-iodopyridine

: 1400287-02-6
tert-butyl 4-(6-(4-fluorophenylamino)-1-(methylsulfonyl)-1H-pyrrolo[3,2-c]pyridin-2-yl)-1H-pyrazole-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 17.67 h / 20 °C / Cooling with ice

2: sodium hydroxide / tetrahydrofuran

3: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 60 °C / Microwave irradiation

4: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / water; tert-butyl alcohol / 1.5 h / 80 °C / Microwave irradiation

With caesium carbonate; triethylamine; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; tert-butyl XPhos; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1093193-29-3
4-ethynyl-1H-pyrazole-1-carboxylate tert-butyl ester

: 1400287-02-6
tert-butyl 4-(6-(4-fluorophenylamino)-1-(methylsulfonyl)-1H-pyrrolo[3,2-c]pyridin-2-yl)-1H-pyrazole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 60 °C / Microwave irradiation

2: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / water; tert-butyl alcohol / 1.5 h / 80 °C / Microwave irradiation

With caesium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; tert-butyl XPhos; In water; N,N-dimethyl-formamide; tert-butyl alcohol;