6-chloro-2-[1-(4,4-difluorocyclohexyl)piperidin-4-yl]-3-oxo-2,3-dihydro-1H-isoindole-4-carbonitrile

Base Information

Chemical Name:6-chloro-2-[1-(4,4-difluorocyclohexyl)piperidin-4-yl]-3-oxo-2,3-dihydro-1H-isoindole-4-carbonitrile
CAS No.:1262418-03-0
Molecular Formula:C₂₀H₂₂ClF₂N₃O
Molecular Weight:393.864
Hs Code.:

Synonyms:6-chloro-2-[1-(4,4-difluorocyclohexyl)piperidin-4-yl]-3-oxo-2,3-dihydro-1H-isoindole-4-carbonitrile

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Chemical Property of 6-chloro-2-[1-(4,4-difluorocyclohexyl)piperidin-4-yl]-3-oxo-2,3-dihydro-1H-isoindole-4-carbonitrile

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Technology Process of 6-chloro-2-[1-(4,4-difluorocyclohexyl)piperidin-4-yl]-3-oxo-2,3-dihydro-1H-isoindole-4-carbonitrile

There total 10 articles about 6-chloro-2-[1-(4,4-difluorocyclohexyl)piperidin-4-yl]-3-oxo-2,3-dihydro-1H-isoindole-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1262417-99-1
2-[1-(4,4-difluorocyclohexyl)piperidin-4-yl]-5-chloro-7-iodo-2,3-dihydro-1H-isoindol-1-one

: copper(l) cyanide

: 1262418-03-0
6-chloro-2-[1-(4,4-difluorocyclohexyl)piperidin-4-yl]-3-oxo-2,3-dihydro-1H-isoindole-4-carbonitrile

Guidance literature:: In N,N-dimethyl-formamide; for 3h; Reflux; Inert atmosphere;

Reference yield:

: 7499-07-2
4-chloro-2-methylbenzoic acid

: 1262418-03-0
6-chloro-2-[1-(4,4-difluorocyclohexyl)piperidin-4-yl]-3-oxo-2,3-dihydro-1H-isoindole-4-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: iodine; [bis(acetoxy)iodo]benzene / palladium diacetate / N,N-dimethyl-formamide / 100 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: dibenzoyl peroxide; N-Bromosuccinimide / Methyl pivalate / 3 h / 85 °C / Inert atmosphere

3.2: 4 h / 90 °C

4.1: N,N-dimethyl-formamide / 3 h / Reflux; Inert atmosphere

With N-Bromosuccinimide; [bis(acetoxy)iodo]benzene; iodine; potassium carbonate; dibenzoyl peroxide; palladium diacetate; In Methyl pivalate; N,N-dimethyl-formamide;

Reference yield:

: 1262417-90-2
tert-butyl (1-(4,4-difluorocyclohexyl)piperidin-4-yl)carbamate

: 1262418-03-0
6-chloro-2-[1-(4,4-difluorocyclohexyl)piperidin-4-yl]-3-oxo-2,3-dihydro-1H-isoindole-4-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / 1,4-dioxane / 20 °C

2.1: dibenzoyl peroxide; N-Bromosuccinimide / Methyl pivalate / 3 h / 85 °C / Inert atmosphere

2.2: 4 h / 90 °C

3.1: N,N-dimethyl-formamide / 3 h / Reflux; Inert atmosphere

With hydrogenchloride; N-Bromosuccinimide; dibenzoyl peroxide; In 1,4-dioxane; Methyl pivalate; N,N-dimethyl-formamide;