1262417-90-2

Upstream product

• 22515-18-0 4,4-difluorocyclohexanone 
• 73874-95-0 (piperidin-4-yl)carbamic acid tert-butyl ester 

Downstream Products

• 1262417-88-8 1-(4,4-difluorocyclohexyl)-piperidin-4-ylamine 
• 1262417-99-1 2-[1-(4,4-difluorocyclohexyl)piperidin-4-yl]-5-chloro-7-iodo-2,3-dihydro-1H-isoindol-1-one 
• 1262418-03-0 6-chloro-2-[1-(4,4-difluorocyclohexyl)piperidin-4-yl]-3-oxo-2,3-dihydro-1H-isoindole-4-carbonitrile 
• 1262418-07-4 2-[1-(4,4-difluorocyclohexyl)piperidin-4-yl]-5-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carbonitrile 

Relevant academic research and scientific papers

BENZAMIDE CGRP RECEPTOR ANTAGONISTS

The present invention is directed to benzamide compounds which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

3-OXO-2, 3-DIHYDRO-LH-ISOINDOLE-4-CARBOXAMIDES AS PARP INHIBITORS

There are provided subs ti tuted 3-ox -2, 3 -dihydro-]H-isoindole-4-carboxamide derivatives (I) which selectively inhibit the activity of poly (ADP-ribose) polymerase PARP- 1 with respect to poly (ADP-ribose) polymerase PARP-2. The compounds of this inven