2-benzyl-1,4,5,6-tetrahydro-cyclopenta[b]pyrrole

Base Information

• Chemical Name: 2-benzyl-1,4,5,6-tetrahydro-cyclopenta[b]pyrrole
• CAS No.: 1422518-51-1
• Molecular Formula: C₁₄H₁₅N
• Molecular Weight: 197.28
• Mol file: 1422518-51-1.mol

Synonyms:2-benzyl-1,4,5,6-tetrahydro-cyclopenta[b]pyrrole

Chemical Property of 2-benzyl-1,4,5,6-tetrahydro-cyclopenta[b]pyrrole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzyl-1,4,5,6-tetrahydro-cyclopenta[b]pyrrole

There total 2 articles about 2-benzyl-1,4,5,6-tetrahydro-cyclopenta[b]pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

Cyclopentanol (96-41-3) + rac-phenylalaninol (1795-98-8,3182-95-4,5267-64-1,16088-07-6) → 2-benzyl-1,4,5,6-tetrahydro-cyclopenta[b]pyrrole (1422518-51-1)

Guidance literature:

With (4-Ph)Triaz(NHPⁱPr₂)₂Mn(CO)₂Br; potassium tert-butylate; In 2-methyltetrahydrofuran; at 110 ℃; for 18h; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1002/anie.201702543

Reference yield: 45.0%

rac-phenylalaninol (1795-98-8,3182-95-4,5267-64-1,16088-07-6) + cyclopentanone (120-92-3) → 2-benzyl-1,4,5,6-tetrahydro-cyclopenta[b]pyrrole (1422518-51-1)

Guidance literature:

With [2,2]bipyridinyl; potassium tert-butylate; nickel dichloride; In toluene; at 130 ℃; for 36h; regioselective reaction; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1039/c8gc00318a

upstream raw materials:

Cyclopentanol

rac-phenylalaninol

cyclopentanone

Refernces

• 1、 Kallmeier, Fabian,Dudziec, Beata,Irrgang, Torsten,Kempe, Rhett. "Manganese-Catalyzed Sustainable Synthesis of Pyrroles from Alcohols and Amino Alcohols". supporting information. p. 7261 - 7265. Retrieved 2017/06/13.
• 2、 Michlik, Stefan,Kempe, Rhett. "A sustainable catalytic pyrrole synthesis". . p. 140 - 144. Retrieved 2013/08/24.