tert-butyl((1S,2S)-1-(4-fluorophenyl)-2-methylbut-3-enyloxy)dimethylsilane

Base Information

Chemical Name:tert-butyl((1S,2S)-1-(4-fluorophenyl)-2-methylbut-3-enyloxy)dimethylsilane
CAS No.:1446121-47-6
Molecular Formula:C₁₇H₂₇FOSi
Molecular Weight:294.485
Hs Code.:

Synonyms:tert-butyl((1S,2S)-1-(4-fluorophenyl)-2-methylbut-3-enyloxy)dimethylsilane

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Chemical Property of tert-butyl((1S,2S)-1-(4-fluorophenyl)-2-methylbut-3-enyloxy)dimethylsilane

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Technology Process of tert-butyl((1S,2S)-1-(4-fluorophenyl)-2-methylbut-3-enyloxy)dimethylsilane

There total 5 articles about tert-butyl((1S,2S)-1-(4-fluorophenyl)-2-methylbut-3-enyloxy)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₆H₂₅FO₂Si

: 1779-49-3
Methyltriphenylphosphonium bromide

: 1446121-47-6
tert-butyl((1S,2S)-1-(4-fluorophenyl)-2-methylbut-3-enyloxy)dimethylsilane

Guidance literature:: Methyltriphenylphosphonium bromide; With n-butyllithium; In tetrahydrofuran; at 0 ℃; for 1h;

C₁₆H₂₅FO₂Si; In tetrahydrofuran; at -60 ℃; for 4h;
DOI:10.1021/ol401458d

Reference yield:

: 1446121-33-0
(S)-4-benzyl-3-((2R,3S)-3-(tert-butyldimethylsilyloxy)-3-(4-fluorophenyl)-2-methylpropanoyl)oxazolidin-2-one

: 1446121-47-6
tert-butyl((1S,2S)-1-(4-fluorophenyl)-2-methylbut-3-enyloxy)dimethylsilane

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium borohydride / tetrahydrofuran; ethanol / 1 h / 0 °C

2.1: potassium carbonate; Dess-Martin periodane / dichloromethane / 1 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran / 1 h / 0 °C

3.2: 4 h / -60 °C

With lithium borohydride; n-butyllithium; potassium carbonate; Dess-Martin periodane; In tetrahydrofuran; ethanol; dichloromethane; 3.1: |Wittig Olefination / 3.2: |Wittig Olefination;
DOI:10.1021/ol401458d

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 1446121-47-6
tert-butyl((1S,2S)-1-(4-fluorophenyl)-2-methylbut-3-enyloxy)dimethylsilane

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; magnesium chloride; chloro-trimethyl-silane / ethyl acetate / 36 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / -78 °C / Inert atmosphere

3.1: lithium borohydride / tetrahydrofuran; ethanol / 1 h / 0 °C

4.1: potassium carbonate; Dess-Martin periodane / dichloromethane / 1 h / 20 °C

5.1: n-butyllithium / tetrahydrofuran / 1 h / 0 °C

5.2: 4 h / -60 °C

With lithium borohydride; n-butyllithium; chloro-trimethyl-silane; potassium carbonate; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine; magnesium chloride; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; 5.1: |Wittig Olefination / 5.2: |Wittig Olefination;
DOI:10.1021/ol401458d