3-[3-(3-{4-[3,3,4,4,5,5-hexafluoro-2-(2-methylthiophen-3-yl)cyclopent-1-enyl]-5-methylthiophen-2-yl}phenoxy)propoxy]pyridine-2-carboxylic acid

Base Information

Chemical Name:3-[3-(3-{4-[3,3,4,4,5,5-hexafluoro-2-(2-methylthiophen-3-yl)cyclopent-1-enyl]-5-methylthiophen-2-yl}phenoxy)propoxy]pyridine-2-carboxylic acid
CAS No.:948836-31-5
Molecular Formula:C₃₀H₂₃F₆NO₄S₂
Molecular Weight:639.639
Hs Code.:

Synonyms:3-[3-(3-{4-[3,3,4,4,5,5-hexafluoro-2-(2-methylthiophen-3-yl)cyclopent-1-enyl]-5-methylthiophen-2-yl}phenoxy)propoxy]pyridine-2-carboxylic acid

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Chemical Property of 3-[3-(3-{4-[3,3,4,4,5,5-hexafluoro-2-(2-methylthiophen-3-yl)cyclopent-1-enyl]-5-methylthiophen-2-yl}phenoxy)propoxy]pyridine-2-carboxylic acid

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Technology Process of 3-[3-(3-{4-[3,3,4,4,5,5-hexafluoro-2-(2-methylthiophen-3-yl)cyclopent-1-enyl]-5-methylthiophen-2-yl}phenoxy)propoxy]pyridine-2-carboxylic acid

There total 6 articles about 3-[3-(3-{4-[3,3,4,4,5,5-hexafluoro-2-(2-methylthiophen-3-yl)cyclopent-1-enyl]-5-methylthiophen-2-yl}phenoxy)propoxy]pyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 948836-30-4
3-[3-(3-{4-[3,3,4,4,5,5-hexafluoro-2-(2-methylthiophen-3-yl)cyclopent-1-enyl]-5-methylthiophen-2-yl}phenoxy)propoxy]pyridine-2-carboxylic acid methyl ester

: 948836-31-5
3-[3-(3-{4-[3,3,4,4,5,5-hexafluoro-2-(2-methylthiophen-3-yl)cyclopent-1-enyl]-5-methylthiophen-2-yl}phenoxy)propoxy]pyridine-2-carboxylic acid

Guidance literature:: With water; sodium carbonate; In methanol; at 50 ℃; for 12h;
DOI:10.1246/cl.2007.888

Reference yield:

: 844475-96-3
1-(2'-bromo-5'-methyl-4'-thienyl)-2-(2'-methyl-3'-thienyl)-3,3,4,4,5,5-hexafluorocyclopentene

: 948836-31-5
3-[3-(3-{4-[3,3,4,4,5,5-hexafluoro-2-(2-methylthiophen-3-yl)cyclopent-1-enyl]-5-methylthiophen-2-yl}phenoxy)propoxy]pyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / tetrahydrofuran / 6 h / 70 °C

2: 70 percent / KOH / dimethylformamide / 6 h / 40 °C

3: 67 percent / sodium carbonate; water / methanol / 12 h / 50 °C

With potassium hydroxide; water; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1246/cl.2007.888

Reference yield:

: 159590-08-6
3,3’-(perfluorocyclopent-1-ene-1,2-diyl)bis(2-methylthiophene)

: 948836-31-5
3-[3-(3-{4-[3,3,4,4,5,5-hexafluoro-2-(2-methylthiophen-3-yl)cyclopent-1-enyl]-5-methylthiophen-2-yl}phenoxy)propoxy]pyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: NBS / acetic acid

2: 75 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / tetrahydrofuran / 6 h / 70 °C

3: 70 percent / KOH / dimethylformamide / 6 h / 40 °C

4: 67 percent / sodium carbonate; water / methanol / 12 h / 50 °C

With potassium hydroxide; N-Bromosuccinimide; water; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1246/cl.2007.888