3-{4-[3,3,4,4,5,5-hexafluoro-2-(2-methylthiophen-3-yl)cyclopent-1-enyl]-5-methylthiophen-2-yl}phenol

Base Information

• Chemical Name: 3-{4-[3,3,4,4,5,5-hexafluoro-2-(2-methylthiophen-3-yl)cyclopent-1-enyl]-5-methylthiophen-2-yl}phenol
• CAS No.: 948836-28-0
• Molecular Formula: C₂₁H₁₄F₆OS₂
• Molecular Weight: 460.464
• Mol file: 948836-28-0.mol

Synonyms:3-{4-[3,3,4,4,5,5-hexafluoro-2-(2-methylthiophen-3-yl)cyclopent-1-enyl]-5-methylthiophen-2-yl}phenol

Chemical Property of 3-{4-[3,3,4,4,5,5-hexafluoro-2-(2-methylthiophen-3-yl)cyclopent-1-enyl]-5-methylthiophen-2-yl}phenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{4-[3,3,4,4,5,5-hexafluoro-2-(2-methylthiophen-3-yl)cyclopent-1-enyl]-5-methylthiophen-2-yl}phenol

There total 2 articles about 3-{4-[3,3,4,4,5,5-hexafluoro-2-(2-methylthiophen-3-yl)cyclopent-1-enyl]-5-methylthiophen-2-yl}phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1-(2'-bromo-5'-methyl-4'-thienyl)-2-(2'-methyl-3'-thienyl)-3,3,4,4,5,5-hexafluorocyclopentene (844475-96-3) + 3-hydroxyphenylboronic acid (87199-18-6) → 3-{4-[3,3,4,4,5,5-hexafluoro-2-(2-methylthiophen-3-yl)cyclopent-1-enyl]-5-methylthiophen-2-yl}phenol (948836-28-0)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 70 ℃; for 6h;

DOI:10.1246/cl.2007.888

Reference yield:

3,3’-(perfluorocyclopent-1-ene-1,2-diyl)bis(2-methylthiophene) (159590-08-6) → 3-{4-[3,3,4,4,5,5-hexafluoro-2-(2-methylthiophen-3-yl)cyclopent-1-enyl]-5-methylthiophen-2-yl}phenol (948836-28-0)

Guidance literature:

Multi-step reaction with 2 steps

1: NBS / acetic acid

2: 75 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / tetrahydrofuran / 6 h / 70 °C

With N-Bromosuccinimide; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; acetic acid;

DOI:10.1246/cl.2007.888

Reference yield: 70.0%

3-{4-[3,3,4,4,5,5-hexafluoro-2-(2-methylthiophen-3-yl)cyclopent-1-enyl]-5-methylthiophen-2-yl}phenol (948836-28-0) + methyl 3-(3-bromopropoxy)pyridine-2-carboxylate (948836-29-1) → 3-[3-(3-{4-[3,3,4,4,5,5-hexafluoro-2-(2-methylthiophen-3-yl)cyclopent-1-enyl]-5-methylthiophen-2-yl}phenoxy)propoxy]pyridine-2-carboxylic acid methyl ester (948836-30-4)

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; at 40 ℃; for 6h;

DOI:10.1246/cl.2007.888

upstream raw materials:

1-(2'-bromo-5'-methyl-4'-thienyl)-2-(2'-methyl-3'-thienyl)-3,3,4,4,5,5-hexafluorocyclopentene

3-hydroxyphenylboronic acid

3,3’-(perfluorocyclopent-1-ene-1,2-diyl)bis(2-methylthiophene)

Downstream raw materials:

C₅₁H₃₅F₁₂BrO₂S₄

3-[3-(3-{4-[3,3,4,4,5,5-hexafluoro-2-(2-methylthiophen-3-yl)cyclopent-1-enyl]-5-methylthiophen-2-yl}phenoxy)propoxy]pyridine-2-carboxylic acid methyl ester

C₅₈H₄₁F₁₂NO₅S₄

3-[3-(3-{4-[3,3,4,4,5,5-hexafluoro-2-(2-methylthiophen-3-yl)cyclopent-1-enyl]-5-methylthiophen-2-yl}phenoxy)propoxy]pyridine-2-carboxylic acid