(3S)-3-{[(R)-(4-chloro-2-fluoro-3-{[4-(hydroxylmethyl)phenyl]carbonyl}phenyl)(cyclopropyl)methyl]amino}butanamide hydrochloride

Base Information

Chemical Name:(3S)-3-{[(R)-(4-chloro-2-fluoro-3-{[4-(hydroxylmethyl)phenyl]carbonyl}phenyl)(cyclopropyl)methyl]amino}butanamide hydrochloride
CAS No.:1433396-22-5
Molecular Formula:C₂₂H₂₄ClFN₂O₃*ClH
Molecular Weight:455.357
Hs Code.:

Synonyms:(3S)-3-{[(R)-(4-chloro-2-fluoro-3-{[4-(hydroxylmethyl)phenyl]carbonyl}phenyl)(cyclopropyl)methyl]amino}butanamide hydrochloride

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Chemical Property of (3S)-3-{[(R)-(4-chloro-2-fluoro-3-{[4-(hydroxylmethyl)phenyl]carbonyl}phenyl)(cyclopropyl)methyl]amino}butanamide hydrochloride

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Technology Process of (3S)-3-{[(R)-(4-chloro-2-fluoro-3-{[4-(hydroxylmethyl)phenyl]carbonyl}phenyl)(cyclopropyl)methyl]amino}butanamide hydrochloride

There total 4 articles about (3S)-3-{[(R)-(4-chloro-2-fluoro-3-{[4-(hydroxylmethyl)phenyl]carbonyl}phenyl)(cyclopropyl)methyl]amino}butanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1433949-49-5
C₂₂H₂₄ClFN₂O₃

: 1433396-22-5
(3S)-3-{[(R)-(4-chloro-2-fluoro-3-{[4-(hydroxylmethyl)phenyl]carbonyl}phenyl)(cyclopropyl)methyl]amino}butanamide hydrochloride

: 1433396-30-5
(3R)-3-{[(R)-(4-chloro-2-fluoro-3-{[4-(hydroxylmethyl)phenyl]carbonyl}phenyl)(cyclopropyl)methyl]amino}butanamide hydrochloride

Guidance literature:: C₂₂H₂₄ClFN₂O₃; Resolution of racemate;

With hydrogenchloride; In ethyl acetate;

Reference yield:

: C₃₄H₄₂ClFN₂O₅S

: 1433396-22-5
(3S)-3-{[(R)-(4-chloro-2-fluoro-3-{[4-(hydroxylmethyl)phenyl]carbonyl}phenyl)(cyclopropyl)methyl]amino}butanamide hydrochloride

: 1433396-30-5
(3R)-3-{[(R)-(4-chloro-2-fluoro-3-{[4-(hydroxylmethyl)phenyl]carbonyl}phenyl)(cyclopropyl)methyl]amino}butanamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: water; lithium hydroxide / tetrahydrofuran / 20 °C

2: triethylamine; ammonium chloride; HATU / N,N-dimethyl-formamide / 20 °C

3: Resolution of racemate

With water; ammonium chloride; triethylamine; HATU; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: lithium 3-{[(R)-(4-chloro-2-fluoro-3-{[4-(hydroxymethyl)phenyl]carbonyl}phenyl)(cyclopropyl)methyl]amino}butanoate

: 1433396-22-5
(3S)-3-{[(R)-(4-chloro-2-fluoro-3-{[4-(hydroxylmethyl)phenyl]carbonyl}phenyl)(cyclopropyl)methyl]amino}butanamide hydrochloride

: 1433396-30-5
(3R)-3-{[(R)-(4-chloro-2-fluoro-3-{[4-(hydroxylmethyl)phenyl]carbonyl}phenyl)(cyclopropyl)methyl]amino}butanamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; ammonium chloride; HATU / N,N-dimethyl-formamide / 20 °C

2: Resolution of racemate

With ammonium chloride; triethylamine; HATU; In N,N-dimethyl-formamide;