[4-({3-[(R)-amino(cyclopropyl)methyl]-6-chloro-2-fluorophenyl}carbonyl)phenyl]methanol

Base Information

Chemical Name:[4-({3-[(R)-amino(cyclopropyl)methyl]-6-chloro-2-fluorophenyl}carbonyl)phenyl]methanol
CAS No.:1433409-40-5
Molecular Formula:C₁₈H₁₇ClFNO₂
Molecular Weight:333.79
Hs Code.:

Synonyms:[4-({3-[(R)-amino(cyclopropyl)methyl]-6-chloro-2-fluorophenyl}carbonyl)phenyl]methanol

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Chemical Property of [4-({3-[(R)-amino(cyclopropyl)methyl]-6-chloro-2-fluorophenyl}carbonyl)phenyl]methanol

Chemical Property:

Purity/Quality:

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Technology Process of [4-({3-[(R)-amino(cyclopropyl)methyl]-6-chloro-2-fluorophenyl}carbonyl)phenyl]methanol

There total 1 articles about [4-({3-[(R)-amino(cyclopropyl)methyl]-6-chloro-2-fluorophenyl}carbonyl)phenyl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1433380-51-8
[4-({3-[(R)-amino(cyclopropyl)methyl]-6-chloro-2-fluorophenyl}carbonyl)phenyl]methanol hydrochloride

: 1433409-40-5
[4-({3-[(R)-amino(cyclopropyl)methyl]-6-chloro-2-fluorophenyl}carbonyl)phenyl]methanol

Guidance literature:: With sodium hydrogencarbonate; In ethyl acetate;

Reference yield:

: 1433409-40-5
[4-({3-[(R)-amino(cyclopropyl)methyl]-6-chloro-2-fluorophenyl}carbonyl)phenyl]methanol

: lithium 3-{[(R)-(4-chloro-2-fluoro-3-{[4-(hydroxymethyl)phenyl]carbonyl}phenyl)(cyclopropyl)methyl]amino}butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium perchlorate / tetrahydrofuran / 336 h / 20 °C

2: water; lithium hydroxide / tetrahydrofuran / 20 °C

With water; lithium perchlorate; lithium hydroxide; In tetrahydrofuran;

Reference yield:

: 1433409-40-5
[4-({3-[(R)-amino(cyclopropyl)methyl]-6-chloro-2-fluorophenyl}carbonyl)phenyl]methanol

: 1433949-49-5
C₂₂H₂₄ClFN₂O₃

Guidance literature:: Multi-step reaction with 3 steps

1: lithium perchlorate / tetrahydrofuran / 336 h / 20 °C

2: water; lithium hydroxide / tetrahydrofuran / 20 °C

3: triethylamine; ammonium chloride; HATU / N,N-dimethyl-formamide / 20 °C

With water; lithium perchlorate; ammonium chloride; triethylamine; HATU; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;