diethyl 3-((4-methoxyphenyl)ethynyl)-5-phenyl-1-tosyl-1H-pyrrole-2,2(5H)-dicarboxylate

Base Information

• Chemical Name: diethyl 3-((4-methoxyphenyl)ethynyl)-5-phenyl-1-tosyl-1H-pyrrole-2,2(5H)-dicarboxylate
• CAS No.: 1342892-05-0
• Molecular Formula: C₃₂H₃₁NO₇S
• Molecular Weight: 573.667
• Mol file: 1342892-05-0.mol

Synonyms:diethyl 3-((4-methoxyphenyl)ethynyl)-5-phenyl-1-tosyl-1H-pyrrole-2,2(5H)-dicarboxylate

Chemical Property of diethyl 3-((4-methoxyphenyl)ethynyl)-5-phenyl-1-tosyl-1H-pyrrole-2,2(5H)-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of diethyl 3-((4-methoxyphenyl)ethynyl)-5-phenyl-1-tosyl-1H-pyrrole-2,2(5H)-dicarboxylate

There total 2 articles about diethyl 3-((4-methoxyphenyl)ethynyl)-5-phenyl-1-tosyl-1H-pyrrole-2,2(5H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

diethyl 3-phenyl-1-tosylaziridine-2,2-dicarboxylate (1132667-67-4) + 1-(4-methoxyphenyl)-1,3-butadiyne (7642-31-1) → diethyl 3-((4-methoxyphenyl)ethynyl)-5-phenyl-1-tosyl-1H-pyrrole-2,2(5H)-dicarboxylate (1342892-05-0)

Guidance literature:

With scandium tris(trifluoromethanesulfonate); In dichloromethane; at 20 ℃; chemoselective reaction; Molecular sieve; Inert atmosphere;

DOI:10.1021/ol202603e

Reference yield:

para-iodoanisole (696-62-8) → diethyl 3-((4-methoxyphenyl)ethynyl)-5-phenyl-1-tosyl-1H-pyrrole-2,2(5H)-dicarboxylate (1342892-05-0)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium/copper catalyst

2: scandium tris(trifluoromethanesulfonate) / dichloromethane / 20 °C / Molecular sieve; Inert atmosphere

With scandium tris(trifluoromethanesulfonate); In dichloromethane; 1: Sonogashira coupling;

DOI:10.1021/ol202603e

upstream raw materials:

diethyl 3-phenyl-1-tosylaziridine-2,2-dicarboxylate

1-(4-methoxyphenyl)-1,3-butadiyne

para-iodoanisole