1-(4-Benzhydryl-piperazin-1-yl)-3-[9-(tetrahydro-pyran-2-yl)-9H-purin-6-yloxy]-propan-2-ol

Base Information

Chemical Name:1-(4-Benzhydryl-piperazin-1-yl)-3-[9-(tetrahydro-pyran-2-yl)-9H-purin-6-yloxy]-propan-2-ol
CAS No.:125346-11-4
Molecular Formula:C₃₀H₃₆N₆O₃
Molecular Weight:528.654
Hs Code.:

Synonyms:1-(4-Benzhydryl-piperazin-1-yl)-3-[9-(tetrahydro-pyran-2-yl)-9H-purin-6-yloxy]-propan-2-ol

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Chemical Property of 1-(4-Benzhydryl-piperazin-1-yl)-3-[9-(tetrahydro-pyran-2-yl)-9H-purin-6-yloxy]-propan-2-ol

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Technology Process of 1-(4-Benzhydryl-piperazin-1-yl)-3-[9-(tetrahydro-pyran-2-yl)-9H-purin-6-yloxy]-propan-2-ol

There total 4 articles about 1-(4-Benzhydryl-piperazin-1-yl)-3-[9-(tetrahydro-pyran-2-yl)-9H-purin-6-yloxy]-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.2%

: 18507-33-0
3-[4-(Diphenylmethyl)-1-piperazinyl]-1,2-propanediol

: 7306-68-5
6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

: 125346-11-4
1-(4-Benzhydryl-piperazin-1-yl)-3-[9-(tetrahydro-pyran-2-yl)-9H-purin-6-yloxy]-propan-2-ol

Guidance literature:: With potassium hydroxide; 18-crown-6 ether; In toluene; for 3h; Ambient temperature;
DOI:10.1021/jm00102a001

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 125346-11-4
1-(4-Benzhydryl-piperazin-1-yl)-3-[9-(tetrahydro-pyran-2-yl)-9H-purin-6-yloxy]-propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / p-toluenesulfonic acid monohydrate / 0.5 h / Heating

2: 10.2 percent / KOH, 18-crown-6 / toluene / 3 h / Ambient temperature

With potassium hydroxide; 18-crown-6 ether; toluene-4-sulfonic acid; In toluene;
DOI:10.1021/jm00102a001

Reference yield:

: 841-77-0
diphenylmethylpiperazine

: 125346-11-4
1-(4-Benzhydryl-piperazin-1-yl)-3-[9-(tetrahydro-pyran-2-yl)-9H-purin-6-yloxy]-propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 1.) 18 h, RT, 2.) 2 h, reflux

2: 10.2 percent / KOH, 18-crown-6 / toluene / 3 h / Ambient temperature

With potassium hydroxide; 18-crown-6 ether; In methanol; toluene;
DOI:10.1021/jm00102a001