18507-33-0Relevant academic research and scientific papers
6-substituted purinyl piperazine derivatives
-
, (2008/06/13)
Novel 6-substituted purinyl piperazine derivatives are described. The novel derivatives are useful as cardiotonic agents and antiarrhythmic agents.
6-substituted purinyl piperazine derivatives
-
, (2008/06/13)
6-substituted purinyl piperazine derivatives and a method of synthesis for the derivatives are described. The 6-substituted purinyl piperazine derivatives are useful as cardiotonic agents and antiarrhythmic agents.
Synthesis and SAR of 6-substituted purine derivatives as novel selective positive inotropes
Press,Falotico,Hajos,Sawyers,Kanojia,Williams,Haertlein,Kauffman,Lakas-Weiss,Salata
, p. 4509 - 4515 (2007/10/02)
A series of purine derivatives was prepared and examined for selective inotropic activity in vitro and in vivo. Thioether-linked derivatives were superior to their oxygen and nitrogen isosteres. Substitution of electron- withdrawing groups on the benzhydryl moiety of these agents increased potency. The best compound of the study, 17 (carsatrin), was examined further and demonstrated selective oral activity as a positive inotrope. These compounds are presumed to act by affecting the kinetics of the cardiac sodium channel by analogy to the prototypic agent DPI 201106 (1). Their high selectivity for increasing contractile force and dP/dt without affecting blood pressure or heart rate is consistent with this mechanism. Carsatrin (17) was selected as a potential development candidate.
4-substituted pyrazolo[3,4-d]pyrimidine derivatives
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, (2008/06/13)
4-Substituted pyrazolo[3,4-d]pyrimidine derivatives and a method of synthesis for the derivatives are described. The 4-substituted pyrazolopyrimidine derivatives are useful as cardiotonic agents and antiarrhythmic agents.
6-substituted purinyl piperazine derivatives
-
, (2008/06/13)
6-Substituted purinyl piperazine derivatives and a method of synthesis for the derivatives are described. The 6-substituted purinyl piperazine derivatives are useful as cardiotonic agents and antiarrhythmic agents.
6-Substituted purinyl piperazine derivatives useful as cardiotonic and antiarrhythmic agents
-
, (2008/06/13)
6-Substituted purinyl piperazine derivatives and a method of synthesis for the derivatives are described. The 6-substituted purinyl piperazine derivatives are useful as cardiotonic agents and antiarrhythmic agents.
4-Substituted pyrazolo[3,4-D]pyrimidine derivatives
-
, (2008/06/13)
4-Substituted pyrazolo[3,4-d]pyrimidine derivatives and a method of synthesis for the derivatives are described. The 4-substituted pyrazolopyrimidine derivatives are useful as cardiotonic agents and antiarryhythmic agents.
