(R)-N-methyl-N-(piperidin-3-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Base Information

Chemical Name:(R)-N-methyl-N-(piperidin-3-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS No.:1374241-90-3
Molecular Formula:C₁₉H₂₃N₅O₂S
Molecular Weight:385.49
Hs Code.:

Synonyms:(R)-N-methyl-N-(piperidin-3-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

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Chemical Property of (R)-N-methyl-N-(piperidin-3-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

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Technology Process of (R)-N-methyl-N-(piperidin-3-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

There total 3 articles about (R)-N-methyl-N-(piperidin-3-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 309956-78-3,172603-05-3
(R)-piperidin-3-ylcarbamic acid tert-butyl ester

: 1374241-90-3
(R)-N-methyl-N-(piperidin-3-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium cyanoborohydride; acetic acid / methanol / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / -30 °C / Inert atmosphere; Reflux

2.2: Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 60 °C

4.1: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / Inert atmosphere; Reflux

With lithium aluminium tetrahydride; ammonium formate; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 454713-13-4,216854-24-9
tert-butyl (R)-(+)-(N-benzylpiperidin-3-yl)carbamate

: 1374241-90-3
(R)-N-methyl-N-(piperidin-3-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / -30 °C / Inert atmosphere; Reflux

1.2: Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 60 °C

3.1: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / Inert atmosphere; Reflux

With lithium aluminium tetrahydride; ammonium formate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1354011-07-6
(R)-1-benzyl-N-methylpiperidine-3-amine

: 1374241-90-3
(R)-N-methyl-N-(piperidin-3-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 60 °C

2: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / Inert atmosphere; Reflux

With ammonium formate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide;