1354011-07-6

Basic information

• Product Name: ((R)-1-Benzyl-piperidin-3-yl)-Methyl-aMine
• Synonyms: ((R)-1-Benzyl-piperidin-3-yl)-Methyl-aMine
• CAS NO: 1354011-07-6
• Molecular Formula: C₁₃H₂₀N₂
• Molecular Weight: 204.3113
• Mol File: 1354011-07-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ((R)-1-Benzyl-piperidin-3-yl)-Methyl-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: ((R)-1-Benzyl-piperidin-3-yl)-Methyl-aMine(1354011-07-6)
• EPA Substance Registry System: ((R)-1-Benzyl-piperidin-3-yl)-Methyl-aMine(1354011-07-6)

Safety Data

• Hazardous Substances Data: 1354011-07-6(Hazardous Substances Data)

Usage

General Description

((R)-1-Benzyl-piperidin-3-yl)-Methyl-aMine is a chemical compound with a molecular formula of C15H22N2. It is a derivative of piperidine and contains a benzyl group. ((R)-1-Benzyl-piperidin-3-yl)-Methyl-aMine has potential psychoactive and stimulant effects on the central nervous system. It is commonly used as a precursor in the synthesis of various psychoactive substances, such as designer drugs. Due to its psychoactive properties, it may also have potential for abuse and dependence. However, detailed information on its pharmacological and toxicological properties is limited, and further research is needed to fully understand its effects on the human body.

Upstream product

• 168466-84-0 (3R)-1-benzyl-3-aminopiperidine 
• 454713-13-4 tert-butyl (R)-(+)-(N-benzylpiperidin-3-yl)carbamate 
• 309956-78-3 (R)-piperidin-3-ylcarbamic acid tert-butyl ester 
• 100-52-7 benzaldehyde 

Downstream Products

• 1374241-94-7 (R)-N-(1-benzylpiperidin-3-yl)-N-methyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 
• 1374239-08-3 (R)-2-(3,5-dichlorophenylamino)-1-(3-(methyl(1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)piperidin-1-yl)ethanone 
• 1374241-92-5 (R)-2-(3,5-dichlorophenylamino)-1-(3-(methyl(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)ethanone 
• 1374241-90-3 (R)-N-methyl-N-(piperidin-3-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1374239-07-2 (R)-2-(3,5-dichlorophenylamino)-1-(3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)ethanone 

Relevant articles and documents

Design, synthesis and evaluation of (R)-3-(7-(methyl?7H-pyrrolo?2, 3-d]pyrimidin-4-yl)amino)-5-azaspiro?2.4]heptan-5-yl)-3-oxopropanenitrile as a JAK1-selective inhibitor

Based on (R)-N-methyl-N-(5-azaspiro?2.4]heptan-7-yl)-7H-pyrrolo?2, 3-d]pyrimidin-4-amine as a core scaffold, we identified (R)-3-(7-(methyl?7H-pyrrolo?2, 3-d]pyrimidin-4-yl)amino)-5-azaspiro?2.4]heptan-5- yl)-3-oxopropanenitrile [(R)-6c] as a JAK1 selective inhibitor. The structural design was based on the combination of tofacitinib's 7-deazapurine and 5-azaspiro?2.4]heptan-7-amine. Compound (R)-6c exhibited an IC50 value of 8.5 nM against JAK1 with a selectivity index of 48 over JAK2. To optimize (R)-6c as a lead compound, we performed in vitro ADME, hERG, kinase profiling, and pharmacokinetic tests. Mouse and rat in vivo studies verified that (R)-6c exhibited desired efficacies in CIA and AIA models.

HETEROCYCLIC TYROSINE KINASE INHIBITORS

The present invention provides compounds useful as inhibitors of Tec family kinases, compositions thereof, and methods of using the same. In certain embodiments, the present invention provides pharmaceutical formulations comprising provided compounds. In certain embodiments, the present invention provides a method of decreasing enzymatic activity of a Tec kinase family member. In some embodiments, such methods include contacting a Tec kinase family member with an effective amount of a Tec kinase family member inhibitor. In certain embodiments, the present invention provides a method of treating a disorder responsive to Tec kinase family inhibition in a subject in need thereof.