(3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2,8-dimethoxyquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

Base Information

Chemical Name:(3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2,8-dimethoxyquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol
CAS No.:1599530-97-8
Molecular Formula:C₃₂H₂₆ClF₃N₆O₃
Molecular Weight:635.045
Hs Code.:

Synonyms:(3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2,8-dimethoxyquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

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Chemical Property of (3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2,8-dimethoxyquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

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Technology Process of (3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2,8-dimethoxyquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

There total 1 articles about (3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2,8-dimethoxyquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1599524-55-6
(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanone

: 1599529-36-8
3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-2,4-dichloro-8-fluoroquinoline

: 124-41-4
sodium methylate

: 1599530-97-8
(3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2,8-dimethoxyquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

Guidance literature:: 3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-2,4-dichloro-8-fluoroquinoline; sodium methylate; In toluene; at 108 - 110 ℃; for 12h; Sealed tube;

(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanone; In tetrahydrofuran; at -78 - 0 ℃; for 0.866667h;

With water; ammonium chloride; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1599530-97-8
(3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2,8-dimethoxyquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

: 1599530-98-9
C₃₂H₂₆ClF₃N₆O₃

: 1599530-99-0
C₃₂H₂₆ClF₃N₆O₃

Guidance literature:: With isopropylamine; In acetonitrile; Resolution of racemate;

Reference yield:

: 1599530-97-8
(3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2,8-dimethoxyquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

: (x)C₄H₆O₄*C₃₂H₂₆ClF₃N₆O₃

Guidance literature:: Multi-step reaction with 2 steps

1: isopropylamine / acetonitrile / Resolution of racemate

2: tetrahydrofuran / 0.25 h

With isopropylamine; In tetrahydrofuran; acetonitrile;