methyl 6-[(E)-2-[4-{(trans-4-bis-ethoxycarbonylmethyl)cyclohexanecarbonylamino}phenyl]-N-(5-methylhexyl)ethenylsulfonamido]hexanoate

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Chemical Name:methyl 6-[(E)-2-[4-{(trans-4-bis-ethoxycarbonylmethyl)cyclohexanecarbonylamino}phenyl]-N-(5-methylhexyl)ethenylsulfonamido]hexanoate
CAS No.:389140-49-2
Molecular Formula:C₃₆H₅₆N₂O₉S
Molecular Weight:692.915
Hs Code.:

Synonyms:methyl 6-[(E)-2-[4-{(trans-4-bis-ethoxycarbonylmethyl)cyclohexanecarbonylamino}phenyl]-N-(5-methylhexyl)ethenylsulfonamido]hexanoate

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Chemical Property of methyl 6-[(E)-2-[4-{(trans-4-bis-ethoxycarbonylmethyl)cyclohexanecarbonylamino}phenyl]-N-(5-methylhexyl)ethenylsulfonamido]hexanoate

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Technology Process of methyl 6-[(E)-2-[4-{(trans-4-bis-ethoxycarbonylmethyl)cyclohexanecarbonylamino}phenyl]-N-(5-methylhexyl)ethenylsulfonamido]hexanoate

There total 6 articles about methyl 6-[(E)-2-[4-{(trans-4-bis-ethoxycarbonylmethyl)cyclohexanecarbonylamino}phenyl]-N-(5-methylhexyl)ethenylsulfonamido]hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 389140-36-7
trans-4-bis-ethoxycarbonylmethyl-1-cyclohexanecarboxylic acid

: methyl 6-[(E)-2-(4-aminophenyl)-N-(5-methylhexyl)ethenylsulfonamido]hexanoate trifluoroacetate

: 389140-49-2
methyl 6-[(E)-2-[4-{(trans-4-bis-ethoxycarbonylmethyl)cyclohexanecarbonylamino}phenyl]-N-(5-methylhexyl)ethenylsulfonamido]hexanoate

Guidance literature:: trans-4-bis-ethoxycarbonylmethyl-1-cyclohexanecarboxylic acid; With pyridine; dicyclohexyl-carbodiimide; for 1h; cooling;

methyl 6-[(E)-2-(4-aminophenyl)-N-(5-methylhexyl)ethenylsulfonamido]hexanoate trifluoroacetate; at 20 ℃; for 48h; Further stages.;
DOI:10.1021/jm010313k

Reference yield:

: 389140-33-4
p-methoxybenzyl 4-oxo-1-cyclohexanecarboxylate

: 389140-49-2
methyl 6-[(E)-2-[4-{(trans-4-bis-ethoxycarbonylmethyl)cyclohexanecarbonylamino}phenyl]-N-(5-methylhexyl)ethenylsulfonamido]hexanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / TiCl₄; pyridine / tetrahydrofuran; CH₂Cl₂ / 10 h / 20 °C

2.1: 36 percent / hydrogen / Pd-C / ethanol / 1 h / 20 °C

3.1: pyridine; DCC / 1 h / cooling

3.2: 34 percent / 48 h / 20 °C

With pyridine; hydrogen; titanium tetrachloride; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm010313k

Reference yield:

: 389140-34-5
p-methoxybenzyl 4-bis-ethoxycarbonylmethylene-1-cyclohexanecarboxylate

: 389140-49-2
methyl 6-[(E)-2-[4-{(trans-4-bis-ethoxycarbonylmethyl)cyclohexanecarbonylamino}phenyl]-N-(5-methylhexyl)ethenylsulfonamido]hexanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 36 percent / hydrogen / Pd-C / ethanol / 1 h / 20 °C

2.1: pyridine; DCC / 1 h / cooling

2.2: 34 percent / 48 h / 20 °C

With pyridine; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm010313k