Thioacetic acid S-[(1R,3S,4S)-2-((R)-1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]hept-3-ylmethyl] ester

Base Information

Chemical Name:Thioacetic acid S-[(1R,3S,4S)-2-((R)-1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]hept-3-ylmethyl] ester
CAS No.:192461-75-9
Molecular Formula:C₁₇H₂₃NOS
Molecular Weight:289.442
Hs Code.:

Synonyms:Thioacetic acid S-[(1R,3S,4S)-2-((R)-1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]hept-3-ylmethyl] ester

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Chemical Property of Thioacetic acid S-[(1R,3S,4S)-2-((R)-1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]hept-3-ylmethyl] ester

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Technology Process of Thioacetic acid S-[(1R,3S,4S)-2-((R)-1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]hept-3-ylmethyl] ester

There total 4 articles about Thioacetic acid S-[(1R,3S,4S)-2-((R)-1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]hept-3-ylmethyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: Methanesulfonic acid (1R,3S,4S)-2-((R)-1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]hept-3-ylmethyl ester

: 10387-40-3
potassium thioacetate

: 192461-75-9
Thioacetic acid S-[(1R,3S,4S)-2-((R)-1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]hept-3-ylmethyl] ester

Guidance literature:: In ethanol; for 15h; Heating;
DOI:10.1016/S0957-4166(97)00118-3

Reference yield:

: 134984-63-7
(1S,3S,4R)-2-((R)-1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]hept-5-ene-3-carboxylic acid ethyl ester

: 192461-75-9
Thioacetic acid S-[(1R,3S,4S)-2-((R)-1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]hept-3-ylmethyl] ester

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / H₂ / 10percent Pd/C / ethyl acetate / 24 h / Ambient temperature

2: 70 percent / LiAlH₄ / tetrahydrofuran / 15 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 5 h / 0 °C

4: 86 percent / ethanol / 15 h / Heating

With lithium aluminium tetrahydride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate;
DOI:10.1016/S0957-4166(97)00118-3

Reference yield:

: 192461-71-5
(1R,3S,4S)-2-<(R)-1-phenylethyl>-2-azabicyclo<2.2.1>heptane-3-exo-methanol

: 192461-75-9
Thioacetic acid S-[(1R,3S,4S)-2-((R)-1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]hept-3-ylmethyl] ester

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 5 h / 0 °C

2: 86 percent / ethanol / 15 h / Heating

With triethylamine; In ethanol; dichloromethane;
DOI:10.1016/S0957-4166(97)00118-3