N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)-benzoyl)benzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide

Base Information

• Chemical Name: N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)-benzoyl)benzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide
• CAS No.: 141626-57-5
• Molecular Formula: C₃₂H₄₆N₂O₇S₂
• Molecular Weight: 634.858
• Mol file: 141626-57-5.mol

Synonyms:N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)-benzoyl)benzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide

Chemical Property of N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)-benzoyl)benzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide

Chemical Property:

Purity/Quality:

> 95% ^*data from raw suppliers

N-Mesyldronedarone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Mesyldronedarone is an impurity of Dronedarone (D679445, HCl); a drug used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.

Technology Process of N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)-benzoyl)benzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide

There total 28 articles about N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)-benzoyl)benzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

4-[3-(di-n-butylamino)-propoxy]-benzoic acid chloride hydrochloride + N-(2-butylbenzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide (141645-85-4) → N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)-benzoyl)benzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide (141626-57-5)

Guidance literature:

iron(III) chloride; In dichloromethane; for 4.25h;

Reference yield: 80.0%

(5-amino-2-butyl-benzofuran-3-yl)-[4-(3-dibutylamino-propoxy)-phenyl]-methanone (141644-91-9) + methanesulfonyl chloride (124-63-0) → N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)-benzoyl)benzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide (141626-57-5)

Guidance literature:

With triethylamine; In chloroform; at 55 ℃; for 1.5h;

DOI:10.1021/op400190b

Reference yield:

(5-amino-2-butyl-benzofuran-3-yl)-[4-(3-dibutylamino-propoxy)-phenyl]-methanone (141644-91-9) + methanesulfonyl chloride (124-63-0) → N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)-benzoyl)benzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide (141626-57-5) + dronedarone (141626-36-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

upstream raw materials:

(5-amino-2-butyl-benzofuran-3-yl)-[4-(3-dibutylamino-propoxy)-phenyl]-methanone

methanesulfonyl chloride

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

(2-butyl-5-nitrobenzofuran-3-yl)(4-(3-(dibutylamino)propoxy)phenyl)methanone

Downstream raw materials:

dronedarone