(S)-N-benzyl-2-amino-3-methoxypropionamide

Base Information

• Chemical Name: (S)-N-benzyl-2-amino-3-methoxypropionamide
• CAS No.: 474534-78-6
• Molecular Formula: C₁₁H₁₆N₂O₂
• Molecular Weight: 208.26
• Mol file: 474534-78-6.mol

Synonyms:(S)-N-benzyl-2-amino-3-methoxypropionamide

Chemical Property of (S)-N-benzyl-2-amino-3-methoxypropionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-benzyl-2-amino-3-methoxypropionamide

There total 13 articles about (S)-N-benzyl-2-amino-3-methoxypropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(S)-N-benzyl-2-N-(benzyloxycarbonyl)amino-3-methoxypropionamide (474534-77-5) → (S)-N-benzyl-2-amino-3-methoxypropionamide (474534-78-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 5h; under 760.051 Torr;

DOI:10.1021/jm2004305

Reference yield: 85.0%

(R)-2-azido-N-benzyl-3-methoxypropanamide → (S)-N-benzyl-2-amino-3-methoxypropionamide (474534-78-6)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; water; at 50 ℃; for 12h; Inert atmosphere;

DOI:10.1055/s-0033-1339901

Reference yield: 75.0%

(S)-N-benzyl-1-tritylaziridine-2-carboxamide (790692-10-3) → (S)-N-benzyl-2-amino-3-methoxypropionamide (474534-78-6)

Guidance literature:

With trifluoroacetic acid; In methanol; chloroform; at 0 ℃; for 8h; Reflux;

DOI:10.1016/j.tetasy.2017.10.018

upstream raw materials:

(S)-N-benzyl-2-N-(benzyloxycarbonyl)amino-3-methoxypropionamide

(S)-N-benzyl-2-N-(benzyloxycarbonyl)amino-3-hydroxypropionamide

benzylamine

N-benzylacrylamide

Downstream raw materials:

lacosamide

C₃₁H₄₄N₂O₃

N-Benzyl-2-Amino-3-Methoxypropionamide

(R)-N-benzyl-2-amino-3-methoxypropanamide N-formyl-L-leucine salt