2-AMino-3-Methoxy-n-(phenylMethyl)propanaMide

Base Information

• Chemical Name: 2-AMino-3-Methoxy-n-(phenylMethyl)propanaMide
• CAS No.: 262845-82-9
• Molecular Formula: C11H16N2O2
• Molecular Weight: 208.26
• Hs Code.: 2922500090
• Mol file: 262845-82-9.mol

Synonyms:2-AMino-3-Methoxy-n-(phenylMethyl)propanaMide

Chemical Property of 2-AMino-3-Methoxy-n-(phenylMethyl)propanaMide

Chemical Property:

• Boiling Point: 421.9±45.0 °C(Predicted)
• PKA: 15.04±0.46(Predicted)
• PSA: 64.35000
• Density: 1.107±0.06 g/cm3(Predicted)
• LogP: 1.36770
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-N-benzyl-3-methoxypropionamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Benzyl-2-amino-3-methoxypropionamide is an impurity of Lacosamide which is a potent anticonvulsant.

Technology Process of 2-AMino-3-Methoxy-n-(phenylMethyl)propanaMide

There total 16 articles about 2-AMino-3-Methoxy-n-(phenylMethyl)propanaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-N-benzyl-2-amino-3-methoxypropionamide (474534-78-6) → N-Benzyl-2-Amino-3-Methoxypropionamide (262845-82-9)

Guidance literature:

With 5-Nitrosalicylaldehyde; In toluene; at 65 ℃; for 16h; Reagent/catalyst;

Reference yield: 99.0%

(R)-N-BENZYL 2-(CARBOBENZYLOXYAMINO)-3-METHOXYPROPIONAMIDE (388619-59-8) → N-Benzyl-2-Amino-3-Methoxypropionamide (262845-82-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 4h; under 760 Torr;

DOI:10.1016/S0968-0896(01)00204-8 DOI:10.1021/jm020225f

Reference yield: 98.5%

N-benzyl-2-bromo-3-methoxypropionamide (705283-58-5) → N-Benzyl-2-Amino-3-Methoxypropionamide (262845-82-9)

Guidance literature:

N-benzyl-2-bromo-3-methoxypropionamide; With sodium carbonate; benzylamine; In water; at 95 ℃; for 2h; Reflux;

With hydrogen; acetic acid; palladium 10% on activated carbon; at 75 ℃; for 2.16667h; under 3750.38 Torr;

upstream raw materials:

(R)-N-BENZYL 2-(CARBOBENZYLOXYAMINO)-3-METHOXYPROPIONAMIDE

(R,S)-N-benzyl 2-N-(benzyloxycarbonyl)amino-3-hydroxypropionamide

benzylamine

N-benzyl-2-bromo-3-methoxypropionamide

Downstream raw materials:

2-acetamido-N-benzyl-3-methoxypropionamide

2-amino-N-benzyl-3-methoxypropionamide monooxalate

lacosamide

(2S)-2-(acetylamino)-N-benzyl-3-methoxypropanamide

Refernces

• 1、 -. "NEW PROCESS". Page/Page column 39-40. . Retrieved 2014/05/24.
• 2、 -. "PROCESS FOR THE PREPARATION OF LACOSAMIDE". Page/Page column 31. . Retrieved 2012/06/15.