N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-(4S)-4-azido-L-proline ethyl ester

Base Information

Chemical Name:N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-(4S)-4-azido-L-proline ethyl ester
CAS No.:126257-61-2
Molecular Formula:C₂₅H₃₂Cl₃N₅O₇
Molecular Weight:620.917
Hs Code.:

N-<N'-<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>-N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-(4S)-4-azido-L-proline ethyl ester

Synonyms:N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-(4S)-4-azido-L-proline ethyl ester

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Chemical Property of N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-(4S)-4-azido-L-proline ethyl ester

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Technology Process of N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-(4S)-4-azido-L-proline ethyl ester

There total 4 articles about N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-(4S)-4-azido-L-proline ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 126294-84-6
N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-(4R)-4-<(methylsulfonyl)oxy>-L-proline ethyl ester

: 126257-61-2
N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-(4S)-4-azido-L-proline ethyl ester

Guidance literature:: With sodium azide; In ethanol; water; for 24h; Heating;
DOI:10.1021/jm00168a013

Reference yield:

: 92893-50-0
N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-N-(2,2,2-trichloroethoxycarbonyl)-L-alanine

: 126257-61-2
N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-(4S)-4-azido-L-proline ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl chloride, DMF / CH₂Cl₂ / 3.5 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / Ambient temperature

3: Et₃N / CH₂Cl₂ / 1 h / 0 °C

4: 94 percent / NaN₃ / ethanol; H₂O / 24 h / Heating

With sodium azide; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In ethanol; dichloromethane; water;
DOI:10.1021/jm00168a013

Reference yield:

: 92893-51-1
(S)-2-[((S)-1-Chlorocarbonyl-ethyl)-(2,2,2-trichloro-ethoxycarbonyl)-amino]-4-phenyl-butyric acid ethyl ester

: 126257-61-2
N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-(4S)-4-azido-L-proline ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / Ambient temperature

2: Et₃N / CH₂Cl₂ / 1 h / 0 °C

3: 94 percent / NaN₃ / ethanol; H₂O / 24 h / Heating

With sodium azide; triethylamine; In ethanol; dichloromethane; water;
DOI:10.1021/jm00168a013