2,6-difluoro-N-(4-(5-methyl-2-(trifluoromethyl)oxazol-4-yl)phenyl)benzamide

Base Information

Chemical Name:2,6-difluoro-N-(4-(5-methyl-2-(trifluoromethyl)oxazol-4-yl)phenyl)benzamide
CAS No.:1582285-86-6
Molecular Formula:C₁₈H₁₁F₅N₂O₂
Molecular Weight:382.29
Hs Code.:

Synonyms:2,6-difluoro-N-(4-(5-methyl-2-(trifluoromethyl)oxazol-4-yl)phenyl)benzamide

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Chemical Property of 2,6-difluoro-N-(4-(5-methyl-2-(trifluoromethyl)oxazol-4-yl)phenyl)benzamide

Chemical Property:

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Technology Process of 2,6-difluoro-N-(4-(5-methyl-2-(trifluoromethyl)oxazol-4-yl)phenyl)benzamide

There total 5 articles about 2,6-difluoro-N-(4-(5-methyl-2-(trifluoromethyl)oxazol-4-yl)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1582285-76-4
4-(5-methyl-2-(trifluoromethyl)oxazol-4-yl)aniline

: 18063-02-0
2,6-difluorobenzoylchloride

: 1582285-86-6
2,6-difluoro-N-(4-(5-methyl-2-(trifluoromethyl)oxazol-4-yl)phenyl)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1582285-77-5
C₁₃H₁₁F₃N₂O₂

: 1582285-86-6
2,6-difluoro-N-(4-(5-methyl-2-(trifluoromethyl)oxazol-4-yl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: dmap / acetonitrile / 20 °C / Inert atmosphere

2: sodium hydroxide; water / tetrahydrofuran; methanol / 0.08 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With dmap; water; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

Reference yield:

: 81112-08-5
N-[4-(2-chloro-1-oxopropyl)phenyl]acetamide

: 1582285-86-6
2,6-difluoro-N-(4-(5-methyl-2-(trifluoromethyl)oxazol-4-yl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / 36 h / 130 °C

2: dmap / acetonitrile / 20 °C / Inert atmosphere

3: sodium hydroxide; water / tetrahydrofuran; methanol / 0.08 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With dmap; water; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;