2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Base Information

Chemical Name:2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
CAS No.:1417782-04-7
Molecular Formula:C₁₉H₁₇ClF₃N₃O₂
Molecular Weight:411.811
Hs Code.:

Synonyms:2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

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Chemical Property of 2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

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Technology Process of 2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

There total 7 articles about 2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.8%

: 1417782-23-0
1-[4-(4-chloro-phenoxy)-2-trifluoromethyl-phenyl]-2-[1,2,4]triazol-1-yl-ethanone

: 925-90-6
ethylmagnesium bromide

: 1417782-04-7
2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Guidance literature:: 1-[4-(4-chloro-phenoxy)-2-trifluoromethyl-phenyl]-2-[1,2,4]triazol-1-yl-ethanone; With magnesium bromide ethyl etherate; In dichloromethane; at 20 ℃; for 1.5h;

ethylmagnesium bromide; In tetrahydrofuran; dichloromethane; at -10 - 20 ℃;

Reference yield:

: 106-48-9,82344-39-6
4-chloro-phenol

: 1417782-04-7
2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 120 - 140 °C

2.1: bromine / diethyl ether / 1.5 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C

3.2: 2.5 h / 20 °C

4.1: magnesium bromide ethyl etherate / dichloromethane / 1.5 h / 20 °C

4.2: -10 - 20 °C

With bromine; sodium hydride; potassium carbonate; magnesium bromide ethyl etherate; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 40161-55-5
1-bromo-4-fluoro-2-(trifluoromethyl)benzene

: 1417782-04-7
2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 110 °C

2.1: TurboGrignard / tetrahydrofuran / 2 h / 20 °C

2.2: 20 °C

3.1: bromine / diethyl ether / 1.5 h / 20 °C

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C

4.2: 2.5 h / 20 °C

5.1: magnesium bromide ethyl etherate / dichloromethane / 1.5 h / 20 °C

5.2: -10 - 20 °C

With TurboGrignard; bromine; sodium hydride; potassium carbonate; magnesium bromide ethyl etherate; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;