1-[2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-2-methoxy-butyl]-1,2,4-triazole

Base Information

Chemical Name:1-[2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-2-methoxy-butyl]-1,2,4-triazole
CAS No.:1417782-10-5
Molecular Formula:C₂₀H₁₉ClF₃N₃O₂
Molecular Weight:425.838
Hs Code.:

Synonyms:1-[2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-2-methoxy-butyl]-1,2,4-triazole

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Chemical Property of 1-[2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-2-methoxy-butyl]-1,2,4-triazole

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Technology Process of 1-[2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-2-methoxy-butyl]-1,2,4-triazole

There total 7 articles about 1-[2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-2-methoxy-butyl]-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1417782-04-7
2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

: 74-88-4
methyl iodide

: 1417782-10-5
1-[2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-2-methoxy-butyl]-1,2,4-triazole

Guidance literature:: 2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; at 20 ℃; for 10h;

Reference yield:

: 106-48-9,82344-39-6
4-chloro-phenol

: 1417782-10-5
1-[2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-2-methoxy-butyl]-1,2,4-triazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 120 - 140 °C

2.1: bromine / diethyl ether / 1.5 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C

3.2: 2.5 h / 20 °C

4.1: magnesium bromide ethyl etherate / dichloromethane / 1.5 h / 20 °C

4.2: -10 - 20 °C

5.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C

5.2: 10 h / 20 °C

With bromine; sodium hydride; potassium carbonate; magnesium bromide ethyl etherate; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 40161-55-5
1-bromo-4-fluoro-2-(trifluoromethyl)benzene

: 1417782-10-5
1-[2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-2-methoxy-butyl]-1,2,4-triazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 110 °C

2.1: TurboGrignard / tetrahydrofuran / 2 h / 20 °C

2.2: 20 °C

3.1: bromine / diethyl ether / 1.5 h / 20 °C

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C

4.2: 2.5 h / 20 °C

5.1: magnesium bromide ethyl etherate / dichloromethane / 1.5 h / 20 °C

5.2: -10 - 20 °C

6.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C

6.2: 10 h / 20 °C

With TurboGrignard; bromine; sodium hydride; potassium carbonate; magnesium bromide ethyl etherate; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;