(1S,6S)-4,6-dimethylcyclohex-3-ene-carboxylic acid [5-(3,3-dimethylbut-1-ynyl)thiophen-3-yl]-(1,4-dioxa-spiro[4.5]dec-8-yl)amide

Base Information

• Chemical Name: (1S,6S)-4,6-dimethylcyclohex-3-ene-carboxylic acid [5-(3,3-dimethylbut-1-ynyl)thiophen-3-yl]-(1,4-dioxa-spiro[4.5]dec-8-yl)amide
• CAS No.: 1263102-06-2
• Molecular Formula: C₂₇H₃₇NO₃S
• Molecular Weight: 455.662
• Mol file: 1263102-06-2.mol

Synonyms:(1S,6S)-4,6-dimethylcyclohex-3-ene-carboxylic acid [5-(3,3-dimethylbut-1-ynyl)thiophen-3-yl]-(1,4-dioxa-spiro[4.5]dec-8-yl)amide

Chemical Property of (1S,6S)-4,6-dimethylcyclohex-3-ene-carboxylic acid [5-(3,3-dimethylbut-1-ynyl)thiophen-3-yl]-(1,4-dioxa-spiro[4.5]dec-8-yl)amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,6S)-4,6-dimethylcyclohex-3-ene-carboxylic acid [5-(3,3-dimethylbut-1-ynyl)thiophen-3-yl]-(1,4-dioxa-spiro[4.5]dec-8-yl)amide

There total 5 articles about (1S,6S)-4,6-dimethylcyclohex-3-ene-carboxylic acid [5-(3,3-dimethylbut-1-ynyl)thiophen-3-yl]-(1,4-dioxa-spiro[4.5]dec-8-yl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[5-(3,3-dimethylbut-1-ynyl)thiophen-3-yl]-(1,4-dioxaspiro[4.5]dec-8-yl)amine (1263102-05-1) + (1S,6S)-4,6-dimethyl-cyclohex-3-enecarboxylic acid (172821-14-6,30631-10-8,58396-02-4) → (1S,6S)-4,6-dimethylcyclohex-3-ene-carboxylic acid [5-(3,3-dimethylbut-1-ynyl)thiophen-3-yl]-(1,4-dioxa-spiro[4.5]dec-8-yl)amide (1263102-06-2)

Guidance literature:

(1S,6S)-4,6-dimethyl-cyclohex-3-enecarboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 ℃; for 2h;

[5-(3,3-dimethylbut-1-ynyl)thiophen-3-yl]-(1,4-dioxaspiro[4.5]dec-8-yl)amine; With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 0 - 20 ℃;

Reference yield:

[5-(3,3-dimethylbut-1-ynyl)thiophen-3-yl]-(1,4-dioxaspiro[4.5]dec-8-yl)amine (1263102-05-1) + C9H13ClO (1314795-31-7) → (1S,6S)-4,6-dimethylcyclohex-3-ene-carboxylic acid [5-(3,3-dimethylbut-1-ynyl)thiophen-3-yl]-(1,4-dioxa-spiro[4.5]dec-8-yl)amide (1263102-06-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 0 - 20 ℃;

Reference yield:

(4S)-3-((4'S,5'S)-1',5'-dimethylcyclohexene-4'-carbonyl)-4-(phenylmethyl)-2-oxazolidinone (90719-43-0) → (1S,6S)-4,6-dimethylcyclohex-3-ene-carboxylic acid [5-(3,3-dimethylbut-1-ynyl)thiophen-3-yl]-(1,4-dioxa-spiro[4.5]dec-8-yl)amide (1263102-06-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 16 h / 20 °C / Cooling with ice

1.2: 1 h

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 0 °C

2.2: 0 - 20 °C

With oxalyl dichloride; lithium hydroxide monohydrate; dihydrogen peroxide; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water;

upstream raw materials:

[5-(3,3-dimethylbut-1-ynyl)thiophen-3-yl]-(1,4-dioxaspiro[4.5]dec-8-yl)amine

C₉H₁₃ClO

(1S,6S)-4,6-dimethyl-cyclohex-3-enecarboxylic acid

(4S)-3-((4'S,5'S)-1',5'-dimethylcyclohexene-4'-carbonyl)-4-(phenylmethyl)-2-oxazolidinone

Downstream raw materials:

(1S,6S)-4,6-dimethyl-cyclohex-3-ene-carboxylic acid [5-(3,3-dimethyl-but-1-ynyl)-thiophen-3-yl]-(trans-4-hydroxy-cyclohexyl)-amide

5-(3,3-dimethyl-but-1-ynyl)-3-[(1S,6S)-(4,6-dimethyl-cyclohex-3-enecarbonyl)-(4-hydroxy-cyclohexyl)-amino]-thiophene-2-carboxylic acid