(S)-methyl 2-((S)-3-(1H-indol-3-yl)-2-(4-methylphenylsulfonamido)propylamino)-3-(1H-indol-3-yl)propanoate

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Chemical Name:(S)-methyl 2-((S)-3-(1H-indol-3-yl)-2-(4-methylphenylsulfonamido)propylamino)-3-(1H-indol-3-yl)propanoate
CAS No.:1264148-75-5
Molecular Formula:C₃₀H₃₂N₄O₄S
Molecular Weight:544.674
Hs Code.:

Synonyms:(S)-methyl 2-((S)-3-(1H-indol-3-yl)-2-(4-methylphenylsulfonamido)propylamino)-3-(1H-indol-3-yl)propanoate

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Chemical Property of (S)-methyl 2-((S)-3-(1H-indol-3-yl)-2-(4-methylphenylsulfonamido)propylamino)-3-(1H-indol-3-yl)propanoate

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Technology Process of (S)-methyl 2-((S)-3-(1H-indol-3-yl)-2-(4-methylphenylsulfonamido)propylamino)-3-(1H-indol-3-yl)propanoate

There total 4 articles about (S)-methyl 2-((S)-3-(1H-indol-3-yl)-2-(4-methylphenylsulfonamido)propylamino)-3-(1H-indol-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 152873-15-9
(S)-3-((1-tosylaziridin-2-yl)methyl)-1H-indole

: 7524-52-9,26988-71-6,5619-09-0,14907-27-8,41222-70-2,67557-19-1,109492-62-8
(S)-tryptophan methyl ester hydrochloride

: 1264148-75-5
(S)-methyl 2-((S)-3-(1H-indol-3-yl)-2-(4-methylphenylsulfonamido)propylamino)-3-(1H-indol-3-yl)propanoate

Guidance literature:: (S)-3-((1-tosylaziridin-2-yl)methyl)-1H-indole; (S)-tryptophan methyl ester hydrochloride; With triethylamine; In tetrahydrofuran; at 0 ℃; for 0.0833333h;

With boron trifluoride diethyl etherate; In tetrahydrofuran; at 0 - 60 ℃; regioselective reaction;
DOI:10.1002/asia.201000554

Reference yield:

: 139712-95-1
C₁₈H₂₀N₂O₃S

: 1264148-75-5
(S)-methyl 2-((S)-3-(1H-indol-3-yl)-2-(4-methylphenylsulfonamido)propylamino)-3-(1H-indol-3-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

2.1: triethylamine / tetrahydrofuran / 0.08 h / 0 °C

2.2: 0 - 60 °C

With triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1.1: Mitsunobu cyclization;
DOI:10.1002/asia.201000554

Reference yield:

: 79659-73-7
N-<(4-Methylphenyl)sulfonyl>tryptophan Methyl Ester

: 1264148-75-5
(S)-methyl 2-((S)-3-(1H-indol-3-yl)-2-(4-methylphenylsulfonamido)propylamino)-3-(1H-indol-3-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

3.1: triethylamine / tetrahydrofuran / 0.08 h / 0 °C

3.2: 0 - 60 °C

With lithium borohydride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 2.1: Mitsunobu cyclization;
DOI:10.1002/asia.201000554