2-[4-(3-{1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclobutyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide

Base Information

Chemical Name:2-[4-(3-{1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclobutyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide
CAS No.:1361188-22-8
Molecular Formula:C₂₃H₂₄N₈O₂
Molecular Weight:444.496
Hs Code.:

Synonyms:2-[4-(3-{1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclobutyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide

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Chemical Property of 2-[4-(3-{1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclobutyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide

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Technology Process of 2-[4-(3-{1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclobutyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide

There total 6 articles about 2-[4-(3-{1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclobutyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1361188-06-8
5-(4-{1-[5-(1H-pyrazol-4-yl)-[1,2,4]oxadiazol-3-yl]cyclobutyl}phenyl)pyrimidin-2-ylamine

: 2675-89-0
2-chloro-N,N-dimethylacetamide

: 1361188-22-8
2-[4-(3-{1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclobutyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm501185j

Reference yield:

: 1361189-49-2
1-[4-(2-aminopyrimidin-5-yl)phenyl]-N-hydroxycyclobutanecarboxamidine

: 1361188-22-8
2-[4-(3-{1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclobutyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / 1-methyl-pyrrolidin-2-one / 0.5 h / 50 °C

1.2: 2 h / 130 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With potassium carbonate; 1,1'-carbonyldiimidazole; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

Reference yield:

: 1361189-40-3
1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclobutanecarbonitrile

: 1361188-22-8
2-[4-(3-{1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclobutyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine / ethanol; water / 16 h / 80 °C / Inert atmosphere

2.1: 1,1'-carbonyldiimidazole / 1-methyl-pyrrolidin-2-one / 0.33 h / 50 °C / Inert atmosphere

2.2: 4 h / 100 °C / Inert atmosphere

3.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With hydroxylamine; caesium carbonate; 1,1'-carbonyldiimidazole; In 1-methyl-pyrrolidin-2-one; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm501185j