(R)-4-Benzyl-3-[(E)-(2R,3S,4R,5R,6R,7R)-3-hydroxy-7-(4-methoxy-benzyloxy)-2,4,6-trimethyl-9-phenyl-5-triethylsilanyloxy-non-8-enoyl]-oxazolidin-2-one

Base Information

Chemical Name:(R)-4-Benzyl-3-[(E)-(2R,3S,4R,5R,6R,7R)-3-hydroxy-7-(4-methoxy-benzyloxy)-2,4,6-trimethyl-9-phenyl-5-triethylsilanyloxy-non-8-enoyl]-oxazolidin-2-one
CAS No.:862465-74-5
Molecular Formula:C₄₂H₅₇NO₇Si
Molecular Weight:716.003
Hs Code.:

Synonyms:(R)-4-Benzyl-3-[(E)-(2R,3S,4R,5R,6R,7R)-3-hydroxy-7-(4-methoxy-benzyloxy)-2,4,6-trimethyl-9-phenyl-5-triethylsilanyloxy-non-8-enoyl]-oxazolidin-2-one

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Chemical Property of (R)-4-Benzyl-3-[(E)-(2R,3S,4R,5R,6R,7R)-3-hydroxy-7-(4-methoxy-benzyloxy)-2,4,6-trimethyl-9-phenyl-5-triethylsilanyloxy-non-8-enoyl]-oxazolidin-2-one

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Technology Process of (R)-4-Benzyl-3-[(E)-(2R,3S,4R,5R,6R,7R)-3-hydroxy-7-(4-methoxy-benzyloxy)-2,4,6-trimethyl-9-phenyl-5-triethylsilanyloxy-non-8-enoyl]-oxazolidin-2-one

There total 7 articles about (R)-4-Benzyl-3-[(E)-(2R,3S,4R,5R,6R,7R)-3-hydroxy-7-(4-methoxy-benzyloxy)-2,4,6-trimethyl-9-phenyl-5-triethylsilanyloxy-non-8-enoyl]-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 862465-90-5
1-(4'R-benzyl-2'-oxo-oxazolidin-3'-yl)-7R-(4-methoxy-benzyloxy)-2R,4S,6R-trimethyl-9-phenyl-5S-(triethyl-silanyloxy)-non-8-ene-1,3-dione

: 862465-74-5
(R)-4-Benzyl-3-[(E)-(2R,3S,4R,5R,6R,7R)-3-hydroxy-7-(4-methoxy-benzyloxy)-2,4,6-trimethyl-9-phenyl-5-triethylsilanyloxy-non-8-enoyl]-oxazolidin-2-one

Guidance literature:: With zinc(II) tetrahydroborate; In diethyl ether; dichloromethane; at -35 - -25 ℃;
DOI:10.1021/ol051225n

Reference yield:

: 862465-71-2
3R-hydroxy-2R-methyl-5-phenyl-pent-4-enoic acid N-methoxy-N-methyl-amide

: 862465-74-5
(R)-4-Benzyl-3-[(E)-(2R,3S,4R,5R,6R,7R)-3-hydroxy-7-(4-methoxy-benzyloxy)-2,4,6-trimethyl-9-phenyl-5-triethylsilanyloxy-non-8-enoyl]-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 99 percent / NaH / dimethylformamide; toluene / 1 h / 0 °C

2.1: 92 percent / DIBAL-H / CH₂Cl₂ / 3 h / -78 °C

3.1: c-HexBCl₃; EtNMe₂ / diethyl ether / 1 h / 0 °C

3.2: 84 percent / diethyl ether / 21 h / -78 - -20 °C

4.1: 82 percent / 2,6-lutidine / CH₂Cl₂ / 1.5 h / -78 °C

5.1: Zn(BH₄)2 / CH₂Cl₂; diethyl ether / -35 - -25 °C

With 2,6-dimethylpyridine; zinc(II) tetrahydroborate; N,N-dimethyl-ethanamine; c-HexBCl₃; sodium hydride; diisobutylaluminium hydride; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene; 3.2: aldol reaction;
DOI:10.1021/ol051225n

Reference yield:

: 862465-72-3
(E)-(2R,3R)-3-(4-Methoxy-benzyloxy)-2-methyl-5-phenyl-pent-4-enal

: 862465-74-5
(R)-4-Benzyl-3-[(E)-(2R,3S,4R,5R,6R,7R)-3-hydroxy-7-(4-methoxy-benzyloxy)-2,4,6-trimethyl-9-phenyl-5-triethylsilanyloxy-non-8-enoyl]-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: c-HexBCl₃; EtNMe₂ / diethyl ether / 1 h / 0 °C

1.2: 84 percent / diethyl ether / 21 h / -78 - -20 °C

2.1: 82 percent / 2,6-lutidine / CH₂Cl₂ / 1.5 h / -78 °C

3.1: Zn(BH₄)2 / CH₂Cl₂; diethyl ether / -35 - -25 °C

With 2,6-dimethylpyridine; zinc(II) tetrahydroborate; N,N-dimethyl-ethanamine; c-HexBCl₃; In diethyl ether; dichloromethane; 1.2: aldol reaction;
DOI:10.1021/ol051225n