3R-hydroxy-2R-methyl-5-phenyl-pent-4-enoic acid N-methoxy-N-methyl-amide

Base Information

Chemical Name:3R-hydroxy-2R-methyl-5-phenyl-pent-4-enoic acid N-methoxy-N-methyl-amide
CAS No.:862465-71-2
Molecular Formula:C₁₄H₁₉NO₃
Molecular Weight:249.31
Hs Code.:

Synonyms:3R-hydroxy-2R-methyl-5-phenyl-pent-4-enoic acid N-methoxy-N-methyl-amide

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Chemical Property of 3R-hydroxy-2R-methyl-5-phenyl-pent-4-enoic acid N-methoxy-N-methyl-amide

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Technology Process of 3R-hydroxy-2R-methyl-5-phenyl-pent-4-enoic acid N-methoxy-N-methyl-amide

There total 1 articles about 3R-hydroxy-2R-methyl-5-phenyl-pent-4-enoic acid N-methoxy-N-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: (E)-(2R,3R)-2-Methyl-5-phenyl-3-trimethylsilanyloxy-pent-4-enethioic acid S-ethyl ester

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 862465-71-2
3R-hydroxy-2R-methyl-5-phenyl-pent-4-enoic acid N-methoxy-N-methyl-amide

Guidance literature:: (E)-(2R,3R)-2-Methyl-5-phenyl-3-trimethylsilanyloxy-pent-4-enethioic acid S-ethyl ester; N,O-dimethylhydroxylamine*hydrochloride; With isopropylmagnesium chloride; In tetrahydrofuran; at -30 - 0 ℃; for 2h;

With hydrogenchloride; In methanol; dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/ol051225n

Reference yield: 99.0%

: 862465-71-2
3R-hydroxy-2R-methyl-5-phenyl-pent-4-enoic acid N-methoxy-N-methyl-amide

: 2746-25-0
p-Methoxybenzyl bromide

: 862465-89-2
3R-(4-methoxy-benzyloxy)-2R-methyl-5-phenyl-pent-4-enoic acid N-methoxy-N-methyl-amide

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; toluene; at 0 ℃; for 1h;
DOI:10.1021/ol051225n

Reference yield:

: 862465-71-2
3R-hydroxy-2R-methyl-5-phenyl-pent-4-enoic acid N-methoxy-N-methyl-amide

: 862465-72-3
(E)-(2R,3R)-3-(4-Methoxy-benzyloxy)-2-methyl-5-phenyl-pent-4-enal

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / NaH / dimethylformamide; toluene / 1 h / 0 °C

2: 92 percent / DIBAL-H / CH₂Cl₂ / 3 h / -78 °C

With sodium hydride; diisobutylaluminium hydride; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol051225n