(1-(2-chloro-6-(trifluoromethyl)benzyl)-4-fluoro-3-iodo-1H-indazol-6-yl)(3-methoxyazetidin-1-yl)methanone

Base Information

Chemical Name:(1-(2-chloro-6-(trifluoromethyl)benzyl)-4-fluoro-3-iodo-1H-indazol-6-yl)(3-methoxyazetidin-1-yl)methanone
CAS No.:1562195-50-9
Molecular Formula:C₂₀H₁₅ClF₄IN₃O₂
Molecular Weight:567.709
Hs Code.:

Synonyms:(1-(2-chloro-6-(trifluoromethyl)benzyl)-4-fluoro-3-iodo-1H-indazol-6-yl)(3-methoxyazetidin-1-yl)methanone

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Chemical Property of (1-(2-chloro-6-(trifluoromethyl)benzyl)-4-fluoro-3-iodo-1H-indazol-6-yl)(3-methoxyazetidin-1-yl)methanone

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Technology Process of (1-(2-chloro-6-(trifluoromethyl)benzyl)-4-fluoro-3-iodo-1H-indazol-6-yl)(3-methoxyazetidin-1-yl)methanone

There total 7 articles about (1-(2-chloro-6-(trifluoromethyl)benzyl)-4-fluoro-3-iodo-1H-indazol-6-yl)(3-methoxyazetidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.4%

: 3-methoxyazetidine hydrochloride

: 1562194-75-5
1-(2-chloro-6-(trifluoromethyl)benzyl)-4-fluoro-3-iodo-1H-indazole-6-carboxylic acid

: 1562195-50-9
(1-(2-chloro-6-(trifluoromethyl)benzyl)-4-fluoro-3-iodo-1H-indazol-6-yl)(3-methoxyazetidin-1-yl)methanone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 40 ℃; for 3h;

Reference yield:

: 885520-23-0
6-bromo-4-fluoro-1H-indazole

: 1562195-50-9
(1-(2-chloro-6-(trifluoromethyl)benzyl)-4-fluoro-3-iodo-1H-indazol-6-yl)(3-methoxyazetidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / 16 h / 70 °C / 2585.81 Torr

2: iodine; potassium hydroxide / N,N-dimethyl-formamide / 4 h / 20 °C

3: caesium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

4: sodium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C

5: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 40 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; iodine; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1227912-19-7
6-bromo-4-fluoro-1H-indazol-3-amine

: 1562195-50-9
(1-(2-chloro-6-(trifluoromethyl)benzyl)-4-fluoro-3-iodo-1H-indazol-6-yl)(3-methoxyazetidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1: hypophosphorous acid; isopentyl nitrite / ethanol / 0 - 20 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / 16 h / 70 °C / 2585.81 Torr

3: iodine; potassium hydroxide / N,N-dimethyl-formamide / 4 h / 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

5: sodium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C

6: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 40 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; iodine; hypophosphorous acid; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; sodium hydroxide; isopentyl nitrite; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;